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RELEVANCE: Smith-Lemli-Opitz syndrome (SLOS) is a human disease caused by mutations in the gene coding for the enzyme DHCR7 (7-dehydrocholesterol (7DHC) reductase), which catalyzes the final step of cholesterol biosynthesis. Accumulated 7DHC in tissues and body fluids of SLOS patients gives rise t...
ORGANISM(S): Mus musculus 
Sucrose is a major carbon source for industrial bioethanol production by Saccharomyces cerevisiae. In yeasts, two modes of sucrose metabolism occur: (i) extracellular hydrolysis by invertase, followed by uptake and metabolism of glucose and fructose, and (ii) uptake via sucrose-H+ symport followed b...
ORGANISM(S): Saccharomyces cerevisiae 
Response of Saccharomyces cerevisiae to Ammonium, L-alanine, or L-glutamine Limitation. The protrotophic laboratory strain CEN.PK113-7D (MAT a) was grown in laboratory fermentors with a working volume of 1 litre at dilution rate (D) of 0.20 per hour (in triplicate for each nitrogen limited condition...
ORGANISM(S): Saccharomyces cerevisiae 
Explore additional off-targets of several PARP inhibitors using Niraparib beads
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044330 | Pride
Explore kinase off-targets of several PARP inhibitors using kinobeads
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045297 | Pride
the protrotophic laboratory strain CEN.PK113-7D (MAT a) was grown in laboratory fermentors with a working volume of 1 litre at dilution rates of 0.02, 0.05, 0.10 (in triplicate), 0.20 (in triplicate), 0.25, and 0.33 per hour (in triplicate). At steady state, samples from each of the 12 continuous cu...
ORGANISM(S): Saccharomyces cerevisiae 
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