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ProteomicsNew preclinical biomarkers for prion diseases in the cerebrospinal fluid proteome revealed by mass spectrometry.
Current diagnostic methods for prion diseases in vivo only work in late stages of the disease when neurodegeneration is very advanced and irreversible. Therefore, the search for biomarkers that can detect the disease before the onset of clinical symptoms is necessary. For this purpose, high-throughp...
ORGANISM(S): Ovis aries 
2025-04-23 | PXD050656 | Pride
Cerebrospinal fluid Swath Mass spectrometry Neurodegenerative diseases Diagnosis Biomarkers. Prion Scrapie Preclinical 
ProteomicsBALF exosomes - Pulmonary Sarcoidosis is Associated With Exosomal Vitamin D-Binding Protein and Inflammatory Molecules
Using 8-plex iTRAQ labelling exosmes isolated from bronchial lavage (BALF) were analyzed by LC-MS/MS. The measurements compared control subjects with sarcoidosis patients (15 in all) ; five with löfgrens syndrome and 10 with regular sacroidosis
ORGANISM(S): Homo sapiens (Human) 
2016-09-27 | PXD001808 | Pride
Sarcoidosis Exosome Balf 
ProteomicsPoor Quantitative Concordance of Proteomic Data between Autopsy Samples and Fresh Frozen Samples from Human Coronary Arteries
Proteomic analyses of human tissues are sometimes conducted on autopsy samples. However, no comparative analysis between proteomic data derived from autopsy samples and fresh frozen samples has been undertaken, nor has there been an assessment of the post-mortem interval (PMI) influences on protein ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-09 | PXD052071 | Pride
Human coronary arteries Smooth muscle cell Post mortem interval Lc-ms/ms Carotid endarterectomies 
UnknownDevelopment and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study.
Not available
S-EPMC4380415 | biostudies-literature
ProteomicsHeLa Pro-IL-1a TurboID LC-MS/MS
Pro-IL-1a is a pro-inflammatory cytokine that is localised to the nucleus in humans due to the presence of a nuclear localisation sequence in its pro-domain. However, some mammals have a predicted loss of fucntion to their nuclear localistion sequence. It is suggested that pro-IL-1a serves as a dual...
ORGANISM(S): Homo sapiens (Human) 
2024-06-28 | PXD053438 | Pride
Inflammation Turboid Biotin ligase proximity labelling Pro-interleukin-1 alpha Histone acetyl transferase Lc-ms/ms 
TranscriptomicsInduction of Pluripotency in Adult Unipotent Germline Stem Cells
Mouse and human stem cells with features similar to those of embryonic stem cells have been derived from testicular cells. Although pluripotent stem cells have been obtained from defined germline stem cells (GSCs) of mouse neonatal testis, only multipotent stem cells have been obtained so far from d...
ORGANISM(S): Mus musculus 
2010-04-09 | E-GEOD-16178 | biostudies-arrayexpress
ProteomicsControl of variant surface glycoprotein expression by CFB2 in African trypanosomes and quantitative proteomic connections to translation and cytokinesis initiation
Variant Surface Glycoproteins (VSG) coat parasitic African trypanosomes and underpin antigenic variation and immune evasion. This VSG is a super-abundant virulence factor that is subject to post-transcriptional gene expression controls mediated via the VSG 3’-untranslated region (3’-UTR). To identif...
ORGANISM(S): Trypanosoma brucei 
2022-02-01 | PXD031351 | Pride
Mrna-binding  pbp1 Trypanosoma brucei  mkt1 Proteomics  rnai. 
TranscriptomicsTranscription profiling of mouse iPS cells from neural stem cells by 2 factors (Oct4, KLF4) (Kim, Zaehres et al.)
Reprogramming of somatic cells is a valuable tool to understand the mechanisms of regaining pluripotency and further opens up the possibility to generate patient-specific pluripotent stem cells. Reprogramming of mouse and human somatic cells into pluripotent stem cells, designated as induced pluripo...
ORGANISM(S): Mus musculus 
2008-10-20 | E-GEOD-10806 | biostudies-arrayexpress
ProteomicsImpact of exercise on the proteome of human peripheral blood mononuclear cells
This project aimed to characterize the impact of high-intensity interval exercise (HIIE) vs. moderate-intensity continuous exercise (MICE) on immune cell proteomics. In a randomized crossover study with 23 young, recreationally active runners, we isolated peripheral blood mononuclear cells (PBMCs) b...
ORGANISM(S): Homo sapiens (Human) 
2025-01-25 | PXD058573 | Pride
Exercise 
UnknownInhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01.
Not available
S-EPMC5506490 | biostudies-literature
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