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ProteomicsRhomboid protease RHBDL2 is a calcium-activated suppressor of EGFR signalling in keratinocytes.
Signalling via the epidermal growth factor receptor (EGFR) is indispensable for morphogenesis and tissue homeostasis. It is activated by extracellular ligands, typically released from transmembrane precursors by proteolysis. Ligand shedding activity is provided by the conserved rhomboid intramembran...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD014766 | Pride
ProteomicsRhomboid mediates membrane protein quality control as an intramembrane protease and adaptor of AAA protease.
Magnesium homeostasis is essential for life and depends on magnesium transporters whose activity and ion selectivity need to be tightly controlled. Rhomboid intramembrane proteases pervade the prokaryotic kingdom but their functions are largely elusive. Using proteomics we find that Bacillus subtili...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2020-01-09 | PXD014578 | Pride
Transporter Er associated degradation Intramembrane protease Manganese Tripletof 5600 Magnesium Bacillus subtilis Lipid membrane Gelc-ms/ms Rhomboid protease Proteostasis Zinc 
ProteomicsAn engineered insulin analog with dual insulin and IGF-1 receptor agonism and distinct signaling
Insulin and insulin-like growth factors (IGF-1 and IGF-2) regulate metabolism, growth, and development via related receptors. In contexts such as brain function or fetal development, coordinated signaling by all three hormones is essential. We report the engineering of [GluB10, D-HisB24, GlyB31, Tyr...
ORGANISM(S): Homo sapiens (Human) 
2026-04-09 | PXD067251 | Pride
Neuroblastoma Sh-sy5y Insulin analog Human Lc-ms/ms 
ProteomicsA quantitative proteomics screen identifies a substrate repertoire of rhomboid protease RHBDL2 in human cells and implicates it in epithelial homeostasis.
Rhomboids are intramembrane serine proteases conserved in all kingdoms of life. They regulate epidermal growth factor receptor signalling in Drosophila by releasing signalling ligands from their transmembrane tethers. Their functions in mammals are poorly understood, in part because of the lack of e...
ORGANISM(S): Homo sapiens (Human) 
2017-08-14 | PXD006716 | Pride
Proteomics Ectodomain shedding Intramembrane protease Epithelia Rhomboid protease Substrate 
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