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MetabolomicsMulti-omics analysis of thermogenic lipolysis in brown adipocytes

The integration of omics technologies into molecular biological research has transformed it into a field where a system can be investigated as a whole by combining information from multiple biochemical layers. This extension of traditional molecular biology, where various data sources are conside...

2025-11-12 | MTBLS12307 | MetaboLights
ProteomicsPlasma proteomics data of hibernating and active wild Scandinavian brown bears
Here we provide mass-spectrometry based plasma proteomics data of hibernating and active wild Scandinavian brown bears (Ursus arctos arctos). The brown bear hibernates for half the year. Despite obesity and the prolonged period of inactivity, bears show no signs of the harmful effects associated wi...
ORGANISM(S): Ursus arctos arctos (European brown bear) 
2021-12-21 | PXD030482 | Pride
Ursus arctos Brown bear Plasma Proteomics Hibernation Lc-ms/ms 
TranscriptomicsBrown Adipose Tissue Harbors a distinct subpopulation of regulatory T cells
Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and ma...
ORGANISM(S): Mus musculus 
2015-06-23 | E-GEOD-64909 | biostudies-arrayexpress
TranscriptomicsWhite-to-brown metabolic conversion of human adipocytes by JAK inhibition
The rising incidence of obesity and related disorders such as diabetes and heart disease has focused considerable attention on the discovery of novel therapeutics. One promising approach has been to increase the number or activity of brown-like adipocytes in white adipose depots, as this has been...
ORGANISM(S): Homo sapiens 
2014-10-31 | E-GEOD-57896 | biostudies-arrayexpress
ProteomicsMulti-omics analysis of thermogenic lipolysis in brown adipocytes
The integration of omics technologies into molecular biological research has transformed it into a field where a system can be investigated as a whole by combining information from multiple biochemical layers. This extension of traditional molecular biology, where various data sources are considered...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-22 | PXD061570 | Pride
Transomics Brown adipocytes Lipolysis Proteomics Thermogenesis Metabolomics Lc-ms Gc-ms Transcriptomics Multi-omics 
TranscriptomicsGene expression from mouse white, brown, and perivascular adipose tissue
Thoracic perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and metabolic syndrome. Surprisingly, PVAT has been reported to share characteristics of both brown and white adipose, but a detailed direct co...
ORGANISM(S): Mus musculus 
2011-08-22 | E-GEOD-28440 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat heart response to hypoxia treatment of parental Fawn Hooded Hypertensive (FHH) and consomic Brown Norway (FHH1BN) rat
Examination of gene expression associated with hypoxia treatment of parental Fawn Hooded Hypertensive (FHH) and consomic Brown Norway (FHH1BN) rat strain. FHH1BN rats are derived from introgression of chromosome 1 from BN rats into the FHH genetic background.
ORGANISM(S): Rattus rattus 
2006-01-15 | E-TIGR-24 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat lung response to hypoxia treatment of parental salt sensitive (SS) and consomic Brown Norway (SSYBN) rat strain
Examination of gene expression associated with hypoxia treatment of parental salt sensitive (SS) and consomic Brown Norway (SSYBN) rat strain. SSYBN rats are derived from introgression of chromosome Y from BN rats into the SS genetic background.
ORGANISM(S): Rattus rattus 
2005-01-01 | E-TIGR-80 | biostudies-arrayexpress
MetabolomicsA metabolomic study of adipose tissue in mice with a disruption of the circadian system

Adipose tissue functions in terms of energy homeostasis as a rheostat for blood triglyceride, regulating its concentration, in response to external stimuli. In addition it acts as a barometer to inform the central nervous system of energy levels which can vary dramatically between meals and accor...

2017-10-27 | MTBLS390 | MetaboLights
TranscriptomicsTranscription profiling of migratory vs sedentary brown trout (Salmo trutta) and wild vs hatchery Atlantic salmon (Salmo salar)
A total of 55 individuals were analysed: 15 migratory brown trout (Salmo trutta) individuals from the Redon river, 15 sedentary brown trout (S. trutta) individuals from the Redon river, 15 sedentary brown trout (S. trutta) individuals from the Chevenne river, and 10 Atlantic salmon (S. salar) indivi...
ORGANISM(S): Salmo salar 
2006-03-27 | E-MEXP-123 | biostudies-arrayexpress
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