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ProteomicsCasein kinase 1 and 2 phosphorylate a conserved cluster of Argonaute to control microRNA functionCasein kinase 1 and 2 phosphorylate a conserved cluster of Argonaute to control microRNA function
MicroRNAs (miRNAs) together with Argonaute (AGO) proteins form the core of the RNA-induced silencing complex (RISC) to regulate gene expression of their target RNAs post-transcriptionally. Argonaute proteins are subjected to intensive regulation via various post-translational modifications that can ...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD043913 | Pride
Argonaute/ck1a1/ck2/microrna/phosphorylation 
ProteomicsThe long non-coding RNA DAGAR is regulated by m6A modification and both pathways are important for smooth muscle cell plasticity
Vascular smooth muscle cells (SMCs) change between a contractile-differentiated and a proliferative-dedifferentiated phenotype in response to environmental cues. Long non-coding RNAs (lncRNAs) and N6-methyladenosine (m6A) modification regulate cell fate decision. Here we used primary human pulmonary...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD029550 | Pride
Smooth muscle cells M6a modifcation Dagar 
ProteomicsKNL2 degradation is regulated by APC/C ubiquitin ligase
Centromeres are specialized chromosomal regions where kinetochore proteins form a protein complex that regulates the cell cycle. KNL2 is an essential protein for kinetochore assembly and plays a significant role in the loading of CENH3. Therefore, the level of KNL2 in plants and other organisms need...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-07-14 | PXD051741 | Pride
Kinetochore null2 Centromeres E3 ligases E2 conjugating enzymes Protein-protein interactions Apc/c D-box 
ProteomicsCasein kinase 1 and 2 phosphorylate a conserved cluster of Argonaute to control microRNA functionCasein kinase 1 and 2 phosphorylate a conserved cluster of Argonaute to control microRNA function
MicroRNAs (miRNAs) together with Argonaute (AGO) proteins form the core of the RNA-induced silencing complex (RISC) to regulate gene expression of their target RNAs post-transcriptionally. Argonaute proteins are subjected to intensive regulation via various post-translational modifications that can ...
ORGANISM(S): Homo sapiens (Human) 
2023-09-13 | PXD044139 | Pride
Argonaute/ck1a1/ck2/microrna/phosphorylation 
ProteomicsArabidopsis TREX components THO5A/B
Characterisation of the Arabidopsis transcription-export (TREX) core complex THO by affinity purification combined with mass spectrometry (AP-MS) revealed that both THO5A and THO5B are components of the complex. Functional assays demonstrate a role in nucleocytosolic mRNA transport in plants.
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-06-16 | PXD049030 | Pride
Ap-ms Arabidopsis Trex Mrna export 
ProteomicsULTRAPETALA1 modulates H3K27me3 and directly enhances POLYCOMB REPRESSIVE COMPLEX 2 activity for fine-tuned reproductive transitions
The antagonistic POLYCOMB (PcG) REPRESSIVE COMPLEX 2 (PRC2) and trithorax (trxG) chromatin machineries play a major role in orchestrating gene expression during the development of multicellular eukaryotes. These complexes are well known for depositing and maintaining the repressive H3K27me3 and acti...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-07-21 | PXD062268 | Pride
Arabidopsis Q-tof 
ProteomicsCytoplasmic DIS3 degrades circular RNAs independently of the exosome
Circular RNAs (circRNAs) are frequently generated during splicing. Their physiological roles, however, remain largely elusive. Some specific circRNAs function as microRNA (miRNA) or RNA binding protein (RBP) sponges or encode for proteins and are actively translated. Due to the lack of accessible en...
ORGANISM(S): Homo sapiens (Human) 
2025-05-05 | PXD050442 | Pride
Exosome Circular rnas Dis3 Degradation Circrna 
ProteomicsThe long non-coding RNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiation
Numerous long non-coding RNAs (lncRNAs) were shown to have functional impact on cellular processes, such as human epidermal homeostasis, but for only a few the mode of action has been elucidated. Here, we report that lncRNA LINC00941 controls keratinocyte differentiation on a global level through as...
ORGANISM(S): Homo sapiens (Human) 
2024-04-08 | PXD043838 | Pride
Long non-coding rna Lc-msms Bivalency Differentiation Epidermis Nurd complex Linc00941 
UnknownCasein kinase 1 and 2 phosphorylate Argonaute proteins to regulate miRNA-mediated gene silencing
Not available
S-SCDT-10_15252-EMBR_202357250 | biostudies-other
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