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UnknownTrans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α-d-mannosidases through a bump-hole strategy.
Not available
S-EPMC10685318 | biostudies-literature
UnknownOptimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition.
Not available
S-EPMC5909127 | biostudies-literature
ProteomicsHepG2 GalNAc-T1/2 Bump-and-hole secretome glycopeptide data
Engineered GalNAc-T glycosyltransferases were used to incorporate a chemically modified GalNAC analog into the secretome of HepG2 cells. The chemical modification included a bioorthogonal alkyne tag that allowed for introduction of a clickable, acid-cleavable biotin-picolyl-azide. Glycoproteins were...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD018048 | Pride
Human Bioorthogonal Galnac-t Liver Glycopeptide Click Secretome Hepg2 
UnknownBump-and-hole engineering of human polypeptide N-acetylgalactosamine transferases to dissect their protein substrates and glycosylation sites in cells.
Not available
S-EPMC9843269 | biostudies-literature
UnknownDevelopment of BromoTag: A "Bump-and-Hole"-PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins.
Not available
S-EPMC8558867 | biostudies-literature
ProteomicsLi et al., Xylosyltransferase Bump-and-hole Engineering to Chemically Manipulate Proteoglycans in Mammalian Cells: CHO-pgs745 cells with 250 uM compound 1
CHO pgs-745 cells transfected with plasmids encoding for WT or bump-and-hole-engineered human XYLT1 or XYLT2 were fed with 6AzGlc-1-phosphate precursor (250 uM) or DMSO and secretome collected. Glycoproteins were clicked with acid-cleavable biotin-alkyne, enriched on neutravidin and on-bead digested...
ORGANISM(S): Cricetulus Griseus (ncbitaxon:10029) 
2025-08-29 | MSV000098977 | MassIVE
ProteomicsLi et al., Xylosyltransferase Bump-and-hole Engineering to Chemically Manipulate Proteoglycans in Mammalian Cells: CHO-pgs745 cells with 50 uM compound 1
CHO pgs-745 cells transfected with plasmids encoding for WT or bump-and-hole-engineered human XYLT1 or XYLT2 were fed with 6AzGlc-1-phosphate precursor (50 uM) or DMSO and secretome collected. Glycoproteins were clicked with acid-cleavable biotin-alkyne, enriched on neutravidin and on-bead digested ...
ORGANISM(S): Cricetulus Griseus (ncbitaxon:10029) 
2025-08-30 | MSV000098983 | MassIVE
ProteomicsK-562 GalNAc-T1/2 Bump-and-hole Whole cell lysate proteomics data
Engineered GalNAc-T glycosyltransferases were used to incorporate a chemically modified GalNAc analog into the glycoproteins on the cell surface of K-562 cells. The chemical modification included a bioorthogonal alkyne tag that allowed for introduction of a clickable, acid-cleavable biotin-picolyl-a...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD017989 | Pride
Human Mucin Bioorthogonal Galnac-t Click Glycoprotein K-562 
UnknownNew Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition.
Not available
S-EPMC4770307 | biostudies-literature
UnknownA Bump-Hole Approach for Directed RNA Editing.
Not available
S-EPMC6386613 | biostudies-literature
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