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ProteomicsCross-link mass spectrometry reveals conformational changes within the N lobe and the activation loop of PDK1 upon dimerization
Cross-linking mass spectrometry analysis of the PDK1 kinase domain dimer that undergoes trans-autophosphorylation.
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031827 | Pride
Pip3 Dimerization Phosphorylation Kinase Pdk1 
ProteomicsMapping of phosphorylation sites on Sgk3 by LC-MS/MS
The phosphorylation profile of Sgk3 protein expressed either in Sf9 insect cells or HEK 293T human cells was assessed by mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026281 | Pride
Activation loop Phosphorylation Sgk3 Turn motif Hydrophobic motif 
ProteomicsMapping and quantification of phosphorylation sites on protein kinase Akt by LC-MS/MS
Mass spectrometry analysis of various Akt species was a cornerstone for elucidating the mechanism of its activation/autoinhibition. By combining intact mass measurements with LC-MS/MS we were able to characterize Akt species comprehensively and relate their biological activity to specific phosphoryl...
ORGANISM(S): Homo sapiens (Human) 
2021-08-13 | PXD022044 | Pride
Growth factor signaling Pip3 Akt1 Lipid second messengers 
UnknownRepeat low-level blast exposure increases transient receptor potential vanilloid 1 (TRPV1) and endothelin-1 (ET-1) expression in the trigeminal ganglion.
Not available
S-EPMC5552217 | biostudies-literature
ProteomicsInvestigating the monomer-dimer transition of PKD1 kinase domain with EDC crosslinking
The project aim was to generate experimental constraints for the in silico modeling of the dimeric structure of the PKD kinase domain. And identify conformational changes upon dimerization. For this we used the heterobifunctional zero length crosslinker EDC to identify salt bridges within the protei...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031997 | Pride
Protein kinase d Kinase domain dimer Activation loop ordering 
UnknownCOVID-19-Specific Suicidal Thoughts and Behaviors in Psychiatrically Hospitalized Adolescents.
Not available
S-EPMC8343358 | biostudies-literature
UnknownCOVID-19 Related Daily Stressors, Coping, and Suicidal Ideation in Psychiatrically Hospitalized Youth.
Not available
S-EPMC8288833 | biostudies-literature
UnknownSocial media use and self-injurious thoughts and behaviors: A systematic review and meta-analysis.
Not available
S-EPMC8243901 | biostudies-literature
UnknownThiazolidinedione use and retinal fluid in the comparison of age-related macular degeneration treatments trials.
Not available
S-EPMC10245276 | biostudies-literature
UnknownPredominantly Persistent Intraretinal Fluid in the Comparison of Age-related Macular Degeneration Treatments Trials.
Not available
S-EPMC10282893 | biostudies-literature
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