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ProteomicsTransposable elements drive regulatory and functional innovation of F box genes
Protein domains of transposable elements (TEs) and viruses increase the protein diversity of host genomes by recombining with other protein domains. By screening 10 million eukaryotic proteins, we identified several domains that define multi-copy gene families and frequently co-occur with TE/viral d...
ORGANISM(S): Caenorhabditis elegans 
2024-12-16 | PXD048290 | Pride
Lc-ms/ms 
ProteomicsGenome maintenance functions of Trypanosoma brucei DNA Polymerase N include telomere association and a role in antigenic variation
Maintenance of genome integrity is critical to guarantee transfer of an intact genome from parent to offspring during cell division. DNA polymerases (Pols) provide roles in both replication of the genome and the repair of a wide range of lesions. Amongst replicative DNA Pols, translesion DNA Pols pl...
ORGANISM(S): Trypanosoma brucei 
2021-09-08 | PXD015648 | Pride
Trypanosomes  vsg 
ProteomicsPiwi proteins and piRNAs in mammalian oocytes and early embryos
Proteomes of whole cell lysate of bovine oocytes, cumulus cells and testis
ORGANISM(S): Bos taurus (Bovine) 
2015-04-01 | PXD001741 | Pride
Lc-msms  bovine  oocytes Testis Cumulus 
ProteomicspiRNA processing by a trimeric Schlafen-domain-containing nuclease
Transposable elements are genomic parasites that expand within and spread between genomes. Piwi proteins control transposon activity, notably in the germline. These proteins recognize their targets through small RNA co-factors named piRNAs, making piRNA biogenesis a key specificity-determining step ...
ORGANISM(S): Caenorhabditis elegans 
2023-10-24 | PXD039502 | Pride
Interactomics  lc-ms/ms 
ProteomicsZBTB10 binds the telomeric variant repeat TTGGGG and interacts with TRF2
Telomeres are the ends of linear chromosomes and together with the shelterin complex present an essential feature for genome integrity. Vertebrate telomeres usually consist of hexameric TTAGGG repeats, however, in cells that use the alternative lengthening of telomeres (ALT) mechanism, variant repea...
ORGANISM(S): Homo sapiens (Human) 
2018-12-17 | PXD010672 | Pride
Interactome  lc-ms/ms 
ProteomicsZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator
Telomeres constitute the ends of linear chromosomes and together with the shelterin complex form a structure essential for genome maintenance and stability. In addition to the constitutive binding of the shelterin complex, other direct, yet more transient interactions are mediated by the CST complex...
ORGANISM(S): Homo sapiens (Human) 
2017-05-11 | PXD006074 | Pride
Zbtb48  hela  u2os  knock-out 
ProteomicsGranulated bovine oocytes represent a lipid rich phenotype with enhanced developmental competence
Immature bovine cumulus-oocytes complexes (COCs) with several layers of tightly packed cumulus cells and a homogeneous, darkish ooplasm are considered to be of good quality, whereas COCs exhibiting cytoplasmatic granulation are frequently observed but routinely discarded. This study compared the pro...
ORGANISM(S): Bos taurus (Bovine) 
2026-05-27 | PXD071722 | Pride
Lc-ms/ms 
ProteomicsQuantitative proteomics of infected macrophages reveals novel Leishmania virulence factors
Leishmaniasis is a major public health problem, causing diseases ranging from self-healing skin lesions to life-threatening chronic infections. Understanding how Leishmania parasites evade the host defense system is crucial for understanding the different manifestations of the disease and for improv...
ORGANISM(S): Mus musculus (Mouse) Leishmania infantum Leishmania mexicana mexicana Leishmania major 
2026-01-28 | PXD058427 | Pride
ProteomicsBaculovirus-mediated expression of a maleness gene in female Anopheles gambiae cells
Rising global temperatures are expected to increase the burden of infectious diseases, including the expansion of mosquito-borne illnesses into new regions. The Anopheles mosquito, the vector of malaria, is a highly sexually dimorphic species; only females require blood meals for egg production and ...
ORGANISM(S): Anopheles gambiae (African malaria mosquito) 
2026-08-24 | PXD070102 | Pride
Lc-ms/ms 
ProteomicsZNF512B associates with mitotic spindles, regulates metaphase exit and is crucial for stem cell differentiation
Zinc finger proteins are a large family of DNA-binding factors that play key roles in diverse cellular processes including gene regulation, RNA metabolism and cell cycle control. The zinc finger protein ZNF512B has recently been implicated in chromatin organization and transcriptional repression thr...
ORGANISM(S): Homo sapiens (Human) 
2026-07-28 | PXD078292 | Pride
Lc-ms/ms 
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