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ProteomicsChemical crosslinking of the SPATA5-SPATA5L1-C1orf109-CINP complex
Here we present data using chemical crosslinking to inform on the architecture of the SPATA5-SPATA5L1-C1orf109-CINP complex (or the 55LCC).
ORGANISM(S): Homo sapiens (Human) 
2024-04-17 | PXD035980 | Pride
55lcc Xl-ms Unfoldase 
UnknownIdentification and characterization of a novel gene, c1orf109, encoding a CK2 substrate that is involved in cancer cell proliferation.
Not available
S-EPMC3546425 | biostudies-literature
UnknownLabeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a late step in human ribosome assembly.
Not available
S-EPMC9004343 | biostudies-literature
ProteomicsIndividual acute depletion of 55LCC-complex members (SILAC-DDA)
HCT116 Cells were CRISPR-Edited, selected and sub-cloned for homocygous endogenous tagged clones. SPATA5 (Q8NB90), SPATA5L1 (Q9BVQ7), CINP (Q9BW66) and C1ORF109 (Q9NX04) were tagged with FKBP12F36V and subjected to 50nM of dTAGV-1 PROTAC molecule or equimolar DMSO solvent control for the indicated t...
ORGANISM(S): Homo sapiens (Human) 
2026-07-29 | PXD064896 | Pride
Spata5l1 C1orf109 55lcc Cinp Spata5 
ProteomicsIndividual acute and rapid depletion of 55LCC-complex members
HCT116 Cells were CRISPR-Edited, selected and sub-cloned for homocygous endogenous tagged clones. SPATA5 (Q8NB90), SPATA5L1 (Q9BVQ7), CINP (Q9BW66) and C1ORF109 (Q9NX04) were tagged with FKBP12F36V and subjected to 50nM of dTAGV-1 PROTAC molecule or equimolar DMSO solvent control for the indicated t...
ORGANISM(S): Homo sapiens (Human) 
2026-07-29 | PXD064619 | Pride
Spata5l1 C1orf109 55lcc Cinp Spata5 
Proteomicspulsed-SILAC after 55LCC depletion
To study the effect of individual protein depletion in 55LCC, we generated CRISPR-based FKBP12F36V-tagged HCT116 cell lines for the following 55LCC members: SPATA5 (Q8NB90) and SPATA5L1 (Q9BVQ7). CINP (Q9BW66), and C1orf109 (Q9NX04). We then performed several characterization experiments during depl...
ORGANISM(S): Homo sapiens (Human) 
2026-07-29 | PXD064721 | Pride
Spata5l1 C1orf109 55lcc Cinp Spata5 
TranscriptomicsA programmed decline in ribosome levels governs human early neurodevelopment
Many neurodevelopmental defects are linked to genes involved in housekeeping functions, such as those encoding ribosome biogenesis factors. How reductions in ribosome biogenesis can result in tissue- and developmental-specific defects remains unclear. Here we describe variants in the ribosome biogen...
ORGANISM(S): Homo sapiens 
2025-04-26 | GSE247456 | GEO
UnknownA programmed decline in ribosome levels governs human early neurodevelopment.
Not available
S-EPMC12339376 | biostudies-literature
UnknownThe SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity.
Not available
S-EPMC11055677 | biostudies-literature
UnknownCryo-EM structure of the AAA+ SPATA5 complex and its role in human cytoplasmic pre-60S maturation.
Not available
S-EPMC12019325 | biostudies-literature
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