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ProteomicsChemical crosslinking of the SPATA5-SPATA5L1-C1orf109-CINP complex
Here we present data using chemical crosslinking to inform on the architecture of the SPATA5-SPATA5L1-C1orf109-CINP complex (or the 55LCC).
ORGANISM(S): Homo sapiens (Human) 
2024-04-17 | PXD035980 | Pride
55lcc Xl-ms Unfoldase 
TranscriptomicsEffect of Cyclin-dependent kinase 2 (CINP) inhibition on TSU-PR1 cell line with stable KLF5 expression May
To study wither loss of CINP rescues global gene expression by KLF5 overexpression, we compare the effect of siRNA-mediated CINP silencing on K12 cells (TSU-PR1 cell line with stable KLF5 expression).
ORGANISM(S): Homo sapiens 
2020-05-15 | GSE98930 | GEO
UnknownFunctional genomic screens identify CINP as a genome maintenance protein.
Not available
S-EPMC2780779 | biostudies-literature
UnknownCINP is a novel cofactor of KLF5 required for its role in the promotion of cell proliferation, survival and tumor growth.
Not available
S-EPMC6294659 | biostudies-literature
UnknownBiomarkers for Psychiatry: The Journey from Fantasy to Fact, a Report of the 2013 CINP Think Tank.
Not available
S-EPMC4648162 | biostudies-literature
GenomicsHomo sapiens
Effect of Cyclin-dependent kinase 2 (CINP) inhibition on TSU-PR1 cell line with stable KLF5 expression May
PRJNA386882 | ENA
UnknownStrategies for Utilizing Neuroimaging Biomarkers in CNS Drug Discovery and Development: CINP/JSNP Working Group Report.
Not available
S-EPMC5604546 | biostudies-literature
ProteomicsIndividual acute depletion of 55LCC-complex members (SILAC-DDA)
HCT116 Cells were CRISPR-Edited, selected and sub-cloned for homocygous endogenous tagged clones. SPATA5 (Q8NB90), SPATA5L1 (Q9BVQ7), CINP (Q9BW66) and C1ORF109 (Q9NX04) were tagged with FKBP12F36V and subjected to 50nM of dTAGV-1 PROTAC molecule or equimolar DMSO solvent control for the indicated t...
ORGANISM(S): Homo sapiens (Human) 
2026-07-29 | PXD064896 | Pride
Spata5l1 C1orf109 55lcc Cinp Spata5 
ProteomicsIndividual acute and rapid depletion of 55LCC-complex members
HCT116 Cells were CRISPR-Edited, selected and sub-cloned for homocygous endogenous tagged clones. SPATA5 (Q8NB90), SPATA5L1 (Q9BVQ7), CINP (Q9BW66) and C1ORF109 (Q9NX04) were tagged with FKBP12F36V and subjected to 50nM of dTAGV-1 PROTAC molecule or equimolar DMSO solvent control for the indicated t...
ORGANISM(S): Homo sapiens (Human) 
2026-07-29 | PXD064619 | Pride
Spata5l1 C1orf109 55lcc Cinp Spata5 
Proteomicspulsed-SILAC after 55LCC depletion
To study the effect of individual protein depletion in 55LCC, we generated CRISPR-based FKBP12F36V-tagged HCT116 cell lines for the following 55LCC members: SPATA5 (Q8NB90) and SPATA5L1 (Q9BVQ7). CINP (Q9BW66), and C1orf109 (Q9NX04). We then performed several characterization experiments during depl...
ORGANISM(S): Homo sapiens (Human) 
2026-07-29 | PXD064721 | Pride
Spata5l1 C1orf109 55lcc Cinp Spata5 
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