Sort   by:  
 Page size 
ProteomicsChemical crosslinking of the SPATA5-SPATA5L1-C1orf109-CINP complex
Here we present data using chemical crosslinking to inform on the architecture of the SPATA5-SPATA5L1-C1orf109-CINP complex (or the 55LCC).
ORGANISM(S): Homo sapiens (Human) 
2024-04-17 | PXD035980 | Pride
55lcc Xl-ms Unfoldase 
UnknownBi-allelic variants in SPATA5L1 lead to intellectual disability, spastic-dystonic cerebral palsy, epilepsy, and hearing loss.
Not available
S-EPMC8546233 | biostudies-literature
UnknownThe SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity.
Not available
S-EPMC11055677 | biostudies-literature
ProteomicsIndividual acute depletion of 55LCC-complex members (SILAC-DDA)
HCT116 Cells were CRISPR-Edited, selected and sub-cloned for homocygous endogenous tagged clones. SPATA5 (Q8NB90), SPATA5L1 (Q9BVQ7), CINP (Q9BW66) and C1ORF109 (Q9NX04) were tagged with FKBP12F36V and subjected to 50nM of dTAGV-1 PROTAC molecule or equimolar DMSO solvent control for the indicated t...
ORGANISM(S): Homo sapiens (Human) 
2026-07-29 | PXD064896 | Pride
Spata5l1 C1orf109 55lcc Cinp Spata5 
ProteomicsIndividual acute and rapid depletion of 55LCC-complex members
HCT116 Cells were CRISPR-Edited, selected and sub-cloned for homocygous endogenous tagged clones. SPATA5 (Q8NB90), SPATA5L1 (Q9BVQ7), CINP (Q9BW66) and C1ORF109 (Q9NX04) were tagged with FKBP12F36V and subjected to 50nM of dTAGV-1 PROTAC molecule or equimolar DMSO solvent control for the indicated t...
ORGANISM(S): Homo sapiens (Human) 
2026-07-29 | PXD064619 | Pride
Spata5l1 C1orf109 55lcc Cinp Spata5 
Proteomicspulsed-SILAC after 55LCC depletion
To study the effect of individual protein depletion in 55LCC, we generated CRISPR-based FKBP12F36V-tagged HCT116 cell lines for the following 55LCC members: SPATA5 (Q8NB90) and SPATA5L1 (Q9BVQ7). CINP (Q9BW66), and C1orf109 (Q9NX04). We then performed several characterization experiments during depl...
ORGANISM(S): Homo sapiens (Human) 
2026-07-29 | PXD064721 | Pride
Spata5l1 C1orf109 55lcc Cinp Spata5 
ProteomicsAP-MS Screening for novel Ribosome Biogenesis factors revealing 55LCC
Data from our initital screening for novel biogenesis factors in human ribosome biogenesis, revealing 55LCC interaction and interaction within 55LCC. Further, the dataset includes 55LCC depletion data trapping the pre-60S, enriching non-released biogenesis factors on the pre-60S. In addition transge...
ORGANISM(S): Homo sapiens (Human) 
2026-07-29 | PXD065526 | Pride
Human Ap-ms Ribosome Spata5l1 55lcc Spata5 Cinp. c1orf109 
UnknownAssociation between kidney function and genetic polymorphisms in atherosclerotic and chronic kidney diseases: A cross-sectional study in Japanese male workers.
Not available
S-EPMC5634546 | biostudies-literature
UnknownCryo-EM structure of the AAA+ SPATA5 complex and its role in human cytoplasmic pre-60S maturation.
Not available
S-EPMC12019325 | biostudies-literature
OtherPooled CRISPR/Cas9 screen for genes that contribute to ribosome biogenesis and turnover
While features of ribosome assembly are shared between species, our understanding of the diversity, complexity, dynamics, and regulation of ribosome production in multicellular organisms remains incomplete. To gain insights into ribosome biogenesis in human cells, we performed a genome wide loss of ...
ORGANISM(S): Homo sapiens 
2022-02-26 | GSE197277 | GEO
Sort   by:  
 Page size