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MetabolomicsMetabolomic determinants of carotid atherosclerosis plaque stability
Our objective is to identify the metabolites associated with stability of carotid atheromatous plaques compared to vulnerable plaques, through a metabolomic approach. Eighty consecutive patients with carotid artery stenosis (CAS) who underwent carotid endarterectomy (CEA) according to current guidel...
2025-06-06 | MTBLS12303 | MetaboLights
TranscriptomicsBiobank of Karolinska Endarterectomy (BiKE)
A biobank collection of carotid plaque samples taken from patients undergoing endarterectomy operations. Samples from carotid plaques and peripheral blood mononuclear cells in a setup with clinical registry data collection. See PMID 22371308 for further details.
ORGANISM(S): Homo sapiens 
2012-03-27 | E-GEOD-21545 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling of human carotid atheroma
The aim of this study was to identify new biomarkers and to investigate pathways involved in the progression of human carotid atheroma. The study was conducted from pieces of carotid endarterectomy collected in 32 hypertensive patients. The samples contained media and neo-intima without adventitia. ...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-MTAB-1470 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of asymptomatic and symptomatic atherosclerotic plaques from the same patient
We compared gene expression profiles between asymptomatic and symptomatic atherosclerotic plaques from the same patient. This was accomplished by analyzing carotid plaques from four patients with bilateral high-grade carotid artery stenoses one being symptomatic (TIA or stroke) and the other asympto...
ORGANISM(S): Homo sapiens 
2006-02-10 | E-MEXP-268 | biostudies-arrayexpress
ProteomicsA Proteomic Atlas of Atherosclerosis: Regional Proteomic Signatures for Plaque Inflammation and Calcification
Background: Using proteomics, we strove to reveal novel molecular subtypes of human atherosclerotic lesions, study their associations with histology and imaging and relate them to long-term cardiovascular outcomes. Methods: 219 samples were obtained from 120 patients undergoing carotid endarterectom...
ORGANISM(S): Homo sapiens (Human) 
2023-11-15 | PXD031052 | Pride
Calcification Tmt-labelling Plaque Cardiovascular outcome prognosis Atherosclerosis Inflammation Carotid endarterectomy 
ProteomicsProteomic profiling of carotid atherosclerotic plaques and adjacent intact arterial segments
Although it is well known that the extracellular matrix composition significantly impacts the development of neointimal hyperplasia and atherosclerosis, the biochemical cues regulating the cell-ECM interactions within the neointima remain obscure. Here, we pairwise collected 14 atherosclerotic plaqu...
ORGANISM(S): Homo sapiens (Human) 
2025-06-05 | PXD035173 | Pride
Atherosclerosis Timstof pro Diapasef Data-independent acquisition 
ProteomicsCarotid endarterectomy tissue and tissue-derived extracellular vesicle proteomes from symptomatic and asymptomatic patients
This study sought to compare how the tissue extracellular vesicle proteome of carotid atherosclerotic plaques differs between symptomatic and asymptomatic patients. Carotid arteries samples were collected from symptomatic and asymptomatic patients undergoing endarterectomies. The specimen was grossl...
ORGANISM(S): Homo sapiens (Human) 
2025-06-30 | PXD052938 | Pride
Atheroslerosis Cardiovascular Carotid Human Extracellular vesicles 
UnknownCost-utility analysis of stenting versus endarterectomy in the International Carotid Stenting Study.
Not available
S-EPMC5341766 | biostudies-literature
ProteomicsVulnerable Carotid Artery Plaques Exhibit Proteolysis, Metabolic Reprogramming and Inflammation
Carotid plaque vulnerability is a current feature that aids in the decision making for ischemic stroke risk prevention. Proteomic analysis of plaque tissue can reveal molecular indicators of instability that complement imaging findings. We sought to identify a proteomic signature distinguishing vuln...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD068148 | Pride
Carotid artery disease Proteomics Stroke Vulnerable features Risk stratification 
ProteomicsExtracellular Matrix Proteomics Identifies Molecular Signature of Atherosclerotic Plaques from Symptomatic Patients
Recent findings have challenged the prevailing histology- or imaging-based definition of the “vulnerable plaque”. To investigate molecular characteristics associated with “clinical instability” of atherosclerosis, we performed a proteomics comparison of the vascular extracellular matrix and associat...
ORGANISM(S): Homo sapiens (Human) 
2017-04-20 | PXD005130 | Pride
Atherosclerosis Proteomics Population study Carotid endarterectomy Gene expression Biomarkers 
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