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ProteomicsComprehensive identification of full-length mRNA isoforms reveals massive diversity of neural cell-surface molecules and illuminates their function in development and disease
Genes encoding cell-surface proteins are crucial for nervous system development and are implicated in neurological disorders. These genes produce alternative mRNA isoforms which remain poorly characterized, impeding our understanding of how disease-associated mutations cause pathology. Here we intro...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-11 | PXD017290 | Pride
Cell-surface molecules Neural development Pacbio sequencing Isoforms 
ProteomicsA magnetic bead-based workflow for sensitive and streamlined cell surface proteomics
Cell-surface proteins represent an important class of molecules for therapeutic targeting and defining cellular phenotypes. However, their enrichment and detection via mass spectrometry-based proteomics remains challenging due to low abundance, posttranslational modifications, hydrophobic regions, a...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-01-21 | PXD043678 | Pride
Lc-ms  mass spectrometry  surfaceomics  cell surface capture  n-glycopeptide enrichment  plasma membrane n-glycoprotein 
ProteomicsRepurposing E3 ubiquitin ligases as cell surface protein degraders using Proteolysis Targeting Antibodies
The majority of current therapeutics targeting plasma membrane receptors function by antagonizing ligand binding or enzymatic activities. Typical mammalian proteins, however, consist of multiple domains executing discrete but coordinated activities, and saturating inhibition of one functional domain...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-05-25 | MSV000089542 | MassIVE
TranscriptomicsHIT: a new versatile protein array platform for multi-analyte phenotyping of surface molecules
We have developed a multi-analyte fluid-phase protein array technology termed high-throughput immunophenotyping using transcription (HIT). This method employs a panel of monoclonal antibodies, each tagged with a unique oligonucleotide sequence that serves as a molecular barcode. After staining a s...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-10665 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse bipotential embryonic liver cells to identify liver progenitor cell surface markers.
This SuperSeries is composed of the following subset Series:; GSE6942: Transcriptional profiling of bipotential embryonic liver cells to identify liver progenitor cell surface markers (moe430a). GSE6957: Transcriptional profiling of bipotential embryonic liver cells to identify liver progenitor cell...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6966 | biostudies-arrayexpress
ProteomicsAstrocyte and neuron cell surface proteomes
We developed, tested and validated a method to determine the cell surface proteomes (CSPs) of striatal astrocytes and neurons. We used this method to study the CSPs and how they change in mouse models of disorders that affect the striatum. We compared our data to postmortem human data to identify di...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2024-02-20 | MSV000094132 | MassIVE
ProteomicsMHC peptides presentation is limited by availability of empty HLA molecules rather than the supply of peptides ligands
Whether the presentation levels of the major histocompatibility complex (MHC, called the human leukocytes antigens, HLA, in humans) is limited by the availability of peptide ligands for loading or by the supply of empty MHC molecules, is a yet unresolved issue. This study aims to tackle this dilemma...
ORGANISM(S): Homo sapiens (Human) 
2018-05-10 | PXD007596 | Pride
Interferon Mhc Peptidome Immunopeptidome Hla 
TranscriptomicsTranscription profiling of mouse bipotential embryonic liver cells to identify liver progenitor cell surface markers (430)
The ability to purify to homogeneity a population of hepatic progenitor cells from adult liver is critical for their characterization prior to any therapeutic application. As a step in this direction, we have utilized gene profiling of a bipotential liver cell line from dpc 14 mouse embryonic liver...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6957 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse bipotential embryonic liver cells to identify liver progenitor cell surface markers (430A)
The ability to purify to homogeneity a population of hepatic progenitor cells from adult liver is critical for their characterization prior to any therapeutic application. As a step in this direction, we have utilized gene profiling of a bipotential liver cell line from dpc 14 mouse embryonic liver...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6942 | biostudies-arrayexpress
ProteomicsHeart surfaceome profiling using biotin capture
Cell surface proteins (surfaceome) represent key signalling and interaction molecules for therapeutic targeting, biomarker profiling, and cellular phenotyping. Understanding the surfaceome of complex tissues including the heart is essential to investigate membrane composition and function in physiol...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000095912 | MassIVE
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