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ProteomicsSelective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites
The centrosome is the master orchestrator of mitotic spindle formation and chromosome segregation in animal cells. Centrosome abnormalities are frequently observed in cancer, but little is known of their origin and about pathways affecting centrosome homeostasis. Here we show that autophagy preserve...
ORGANISM(S): Homo sapiens (Human) 
2019-09-12 | PXD014829 | Pride
Centrosome Selective autophagy Centrosome fragmentation Gabarap Mitosis Cep131 Autophagy Centriolar satellites Pcm1 
ProteomicsCentriolar satellites expedite mother centriole remodeling to promote ciliogenesis
Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by PCM1. To study the requirement for centriolar satellites, we generated mice lacking PCM1. Pcm1-/- mice display partially expressive perinatal lethality with survivors exhibiting hydrocephalus, oligospermia...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD031920 | Pride
Mtecs Cilia 
GenomicsDifferential requirement for centriolar satellites in cilium formation and ciliary signaling among different vertebrate cells
Differential requirement for centriolar satellites in cilium formation and ciliary signaling among different vertebrate cells
PRJNA507257 | ENA
TranscriptomicsDifferential requirement for centriolar satellites in cilium formation and ciliary signaling among different vertebrate cells
Centriolar satellites are an array of membrane-less granules that localize and move around the vertebrate centrosome/cilium complex. They have recently emerged as key regulators of the biogenesis and function of the centrosome/cilium-complex and their mutations are linked to ciliopathies. Although c...
ORGANISM(S): Mus musculus Homo sapiens 
2018-11-28 | GSE123017 | GEO
ProteomicsThe Centriolar Satellite Component CEP131 timely regulates mitochondrial Apoptosis
Centriolar satellites are multiprotein aggregates that orbit the centrosome and govern centrosome homeostasis and primary cilia formation. In contrast to the scaffold PCM1, which nucleates centriolar satellites and has been linked to microtubule dynamics, autophagy, and intracellular trafficking, th...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042470 | Pride
Mitochondria Centriolar satellites Cep131 Apoptosis 
UnknownCentriolar satellites are acentriolar assemblies of centrosomal proteins.
Not available
S-EPMC6627235 | biostudies-literature
UnknownCentriolar satellites expedite mother centriole remodeling to promote ciliogenesis.
Not available
S-EPMC9998092 | biostudies-literature
UnknownCentriolar Satellites Control GABARAP Ubiquitination and GABARAP-Mediated Autophagy.
Not available
S-EPMC5526835 | biostudies-literature
UnknownCentriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis.
Not available
S-EPMC2169353 | biostudies-literature
ProteomicsIdentification of the Drosophila centriolar satellite proximity interactome by direct and indirect biotin proximity labeling
In this set of experiments we identified the main scaffolding component of centriolar satellites, PCM1 or Cmb in Drosophila as a proximity interactor of the centriolar structural protein Sas4 by BioID in S2 cells and subsequently explored the Cmb proximity interactome by direct TurboID in S2 cells a...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-03-31 | PXD049372 | Pride
D. melanogaster  centrosome  centriolar satellites  interaction mapping  bioid  turboid 
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