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TranscriptomicsLineage recording in human cerebral organoids (whole organoids)
Induced pluripotent stem cell (iPSC) derived organoid systems provide models to study human organ development. Single-cell transcriptome sequencing enables highly-resolved descriptions of cell state heterogeneity within these systems and computational methods can reconstruct developmental trajectori...
ORGANISM(S): Homo sapiens 
2021-11-03 | E-MTAB-10974 | biostudies-arrayexpress
ProteomicsCerebral organoids proteomics - Human Cerebral Organoids and Fetal Brain Tissue Share Proteomic Similarities
Pluripotent stem cells (PSC) can differentiate inot any cell type of an organism. Their remarkable capability of self-organization enables the formation of three-dimensional structures that resembles miniature organs, including cerebral organoids. These organoids can recreate early steps of the hum...
ORGANISM(S): Homo sapiens (Human) 
2019-11-15 | PXD011605 | Pride
Pluripotent stem cell Progenitors Cerebral organoids Neural Minibrain 
ProteomicsProteome landscape of schizophrenia in patient-derived cerebral organoids
We utilized patient-derived induced pluripotent stem cells (iPSCs) to generate 3D cerebral organoids to model neuropathology of Scz during this critical period. We discovered that Scz organoids exhibited ventricular neuropathology resulting in altered progenitor survival and disrupted neurogenesis. ...
ORGANISM(S): Homo sapiens (Human) 
2021-11-17 | PXD027812 | Pride
Schizophrenia Ipsc Proteome Cerebral organoids Neuropathology 
TranscriptomicsLineage recording in human cerebral organoids (Visium)
Induced pluripotent stem cell (iPSC) derived organoid systems provide models to study human organ development. Single-cell transcriptome sequencing enables highly-resolved descriptions of cell state heterogeneity within these systems and computational methods can reconstruct developmental trajectori...
ORGANISM(S): Homo sapiens 
2021-11-03 | E-MTAB-10972 | biostudies-arrayexpress
TranscriptomicsLineage recording in human cerebral organoids (iTracer-perturb)
Induced pluripotent stem cell (iPSC) derived organoid systems provide models to study human organ development. Single-cell transcriptome sequencing enables highly-resolved descriptions of cell state heterogeneity within these systems and computational methods can reconstruct developmental trajectori...
ORGANISM(S): Homo sapiens 
2021-11-03 | E-MTAB-10971 | biostudies-arrayexpress
TranscriptomicsLineage recording in human cerebral organoids (microdissected)
Induced pluripotent stem cell (iPSC) derived organoid systems provide models to study human organ development. Single-cell transcriptome sequencing enables highly-resolved descriptions of cell state heterogeneity within these systems and computational methods can reconstruct developmental trajectori...
ORGANISM(S): Homo sapiens 
2021-11-03 | E-MTAB-10973 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of great ape cerebral organoids
The human brain has changed dramatically from other primate species, but the genetic and developmental mechanisms behind the differences remains unclear. Here we used single cell RNA sequencing based on 10X technology to explore temporal transcriptomic dynamics and cellular heterogeneity in cerebral...
ORGANISM(S): Pan troglodytes 
2019-12-30 | E-MTAB-7552 | biostudies-arrayexpress
ProteomicsProteomic analysis of Cerebral organoid-derived exsome
In this study, we provides a comprehensive analysis of proteomic changes in exosomes derived from cerebral organoids during neuronal differentiation.
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD063105 | Pride
Exosome Cerebral organoids Proteome 
TranscriptomicsBulk ATAC-seq of primate cerebral organoids
Bulk ATAC-seq was performed on human, chimpanzee, bonobo, and macaque stem cell-derived cerebral organoids. ATAC-seq was performed on day 60 (2 months old) and day 120 (4 months old) cerebral organoids.
ORGANISM(S): Pan paniscus 
2019-10-16 | E-MTAB-8228 | biostudies-arrayexpress
TranscriptomicsSingle-cell transcriptome of cerebral organoids with and without methanol fixation
To study how methanol fixation affects single-cell transcriptomic measurement, two cerebral organoids were dissociated. Cell suspension of each organoid was split into two aliquots. Methanol fixation was applied to one of the two aliquots. Single-cell RNA-seq with 10x Genomics was applied to the two...
ORGANISM(S): Homo sapiens 
2020-08-31 | E-MTAB-9473 | biostudies-arrayexpress
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