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ProteomicsChronic exposure to chewing tobacco induces growth in normal oral cells via overexpression of Stearoyl-CoA desaturase
The practice of using chewing tobacco is common in certain socio-economic sections of southern Asia particularly in the Indian subcontinent. The molecular mechanism of smokeless tobacco which leads to malignancy is unclear. Chewing tobacco demonstrates a carcinogenic effect through chronic and not a...
ORGANISM(S): Homo sapiens (Human) 
2016-12-14 | PXD001554 | Pride
Chewing tobacco Head and neck squamous cell carcinoma Quantitative proteomics 
ProteomicsChronic exposure to chewing tobacco induces metabolic reprogramming and cancer stem cell-like properties in esophageal epithelial cells
Tobacco in its smoke and smokeless form are major risk factors for ESCC (esophageal squamous cell carcinoma). However, molecular alterations associated with smokeless tobacco exposure are poorly understood. In the Indian subcontinent, tobacco is predominantly consumed in chewing form. An understandi...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD013396 | Pride
Cancer stem cells Chewing tobacco Esophageal cancer Metabolic reprogramming 
ProteomicsMolecular alterations elicited by chronic exposure to cigarette smoke and chewing tobacco in oral keratinocytes
Tobacco is mainly consumed in two different forms (smoking and chewing) that vary in their composition and methods of intake. Despite being the leading cause of oral cancer, the molecular mechanisms resulting in malignancy upon tobacco exposure are yet to be fully elucidated. We therefore sought to ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD007127 | Pride
Chronic exposure Orbitrap fusion Carcinogenesis High-throughput Smoking 
ProteomicsIdentification of serum-based biomarkers in oral cancer among tobacco users
Oral cancer is the leading cancer worldwide with significant morbidity and mortality rate. Use of tobacco in form of both chewing and smoking have been known as major risk factors along with alcohol and HPV infection. Despite such knowledge, there are yet no proper screening strategy employed for sc...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD019014 | Pride
Oscc Serum proteomics Smoke Tobacco Mass spectrometry 
TranscriptomicsAssessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens (buccal epithelial cells-mRNA dataset)
Cigarette smoke (CS) is affecting considerably the oral mucosa. Heating, instead of burning, tobacco reduces consistently the amount of toxic compounds and may exert a lower impact on oral health than combusted cigarettes. The carbon-heated tobacco product 1.2 (CHTP1.2) is a potential modified risk ...
ORGANISM(S): Homo sapiens 
2018-03-07 | E-MTAB-6542 | biostudies-arrayexpress
TranscriptomicsAssessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens (gingival epithelial cells-mRNA dataset)
Cigarette smoke (CS) is affecting considerably the oral mucosa. Heating, instead of burning, tobacco reduces consistently the amount of toxic compounds and may exert a lower impact on oral health than combusted cigarettes. The carbon-heated tobacco product 1.2 (CHTP1.2) is a potential modified risk ...
ORGANISM(S): Homo sapiens 
2018-03-07 | E-MTAB-6537 | biostudies-arrayexpress
TranscriptomicsAssessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens (buccal epithelial cells-microRNA dataset)
Cigarette smoke (CS) is affecting considerably the oral mucosa. Heating, instead of burning, tobacco reduces consistently the amount of toxic compounds and may exert a lower impact on oral health than combusted cigarettes. The carbon-heated tobacco product 1.2 (CHTP1.2) is a potential modified risk ...
ORGANISM(S): Homo sapiens 
2018-03-07 | E-MTAB-6543 | biostudies-arrayexpress
TranscriptomicsAssessment of the impact of aerosol from a potential modified risk tobacco product compared with cigarette smoke on human organotypic oral epithelial cultures under different exposure regimens (gingival epithelial cells-microRNA dataset).
Cigarette smoke (CS) is affecting considerably the oral mucosa. Heating, instead of burning, tobacco reduces consistently the amount of toxic compounds and may exert a lower impact on oral health than combusted cigarettes. The carbon-heated tobacco product 1.2 (CHTP1.2) is a potential modified risk ...
ORGANISM(S): Homo sapiens 
2018-03-07 | E-MTAB-6538 | biostudies-arrayexpress
ProteomicsComparative Proteomic Analysis of Saliva from Chewing Tobacco Users and Oral Cancer Patients Reveals Shared Biomarkers
Objectives: The aim of this study was to investigate the salivary proteomic profile of smokeless tobacco users in comparison to non-smokers using LC-MS/MS and to investigate the biological changes associated with smokeless tobacco use and oral cancer. Materials & Methods: Saliva samples of 65 partic...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD045926 | Pride
Saliva Oral cancer Proteomics Chewing tobacco Lc-ms/ms 
MetabolomicsBotanical collections as an opportunity to explore nature through the time: An untargeted metabolomic study in historical and modern Nicotiana leaves

The living and dried specimens in botanical collections play an important role in society for scientific and recreational purposes, offering the opportunity to obtain both macroscopic and molecular information for individual plants, ecosystems, and environmental studies. Untargeted metabolomics i...

2024-03-06 | MTBLS4564 | MetaboLights
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