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ProteomicsSPT6 functions in transcriptional pause/release via PAF1C recruitment
In vitro studies identified various factors including P-TEFb, SEC, SPT6, PAF1, DSIF, and NELF functioning at different stages of transcription elongation driven by RNA polymerase II (RNA Pol II). What remains unclear is how these factors cooperatively regulate pause/release and productive elongation...
ORGANISM(S): Homo sapiens (Human) 
2022-08-09 | PXD033771 | Pride
Human Spt6 Paf1c 
ProteomicsMALDI-MSI-guided LCM-MS: Advancing spatial multi-omics in mouse brain tissue
Spatial multi-omics involves the analysis of biomolecules such as proteome, metabolome, and lipidome within their native spatial context in tissues or cells. This approach provides a comprehensive understanding of biomolecular networks in specific biological environments. Mass spectrometry imaging (...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-07 | PXD060073 | Pride
Lcm-ms Spatial omics Maldi-msi 
ProteomicsCalpain activity is regulated by a KCTD7–cullin 3 complex via non-degradative ubiquitination
Calpains are a class of non-lysosomal cysteine proteases that exert their regulatory functions via limited proteolysis of their substrates. Similar to the lysosomal and proteasomal systems, calpain dysregulation is implicated in the pathogenesis of neurodegenerative disease and cancer. Despite inten...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038842 | Pride
Human Pasef Calpain 
ProteomicsEvolution of the Umbilical Cord Blood Proteome Across Gestational Development
Neonatal health is dependent on early risk stratification, diagnosis, and timely management of many potentially devastating conditions. Preterm infants are at increased risk of prematurity-related complications, including: early-onset sepsis, chronic lung disease, intraventricular hemorrhage, necrot...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051974 | Pride
Cord blood Proteomics Immune development Neonatal immunology Prematurity Biomarker development 
ProteomicsEnhanced Staphylococcus aureus vaccine protection by uncoupling of the alpha-toxin-ADAM10 interaction
Staphylococcus aureus is the leading global cause of bacterial infection-associated mortality, as vaccine development has been elusive. S. aureus alpha-toxin (Hla) is an essential virulence factor in disease. In children, the anti-Hla neutralizing antibody response is the only known correlate of hum...
ORGANISM(S): Escherichia coli 
2024-08-13 | PXD047859 | Pride
Disulfide bond Lc-ms/ms 
ProteomicsSpatial proteomics of Onchocerca volvulus with pleomorphic neoplasms show local and systemic dysregulation of protein expression
Onchocerca volvulus is the agent of onchocerciasis or river blindness and targeted by WHO for elimination. The main strategy is mass drug administration with ivermectin for the duration of the life span of the adult worms. The drug is mainly microfilaricidal, but weak macrofilaricidal effects, after...
ORGANISM(S): Onchocerca volvulus 
2025-02-26 | PXD056237 | Pride
Laser capture microdissection Onchocerca volvulus Lc-ms/ms 
ProteomicsDecoding novel acquired resistance mechanisms in auxin-inducible protein degradation
Loss of function studies played a critical role in dissecting gene function and downstream regulation networks. However, the most used knockout approaches, including CRISPR/Cas9, Cre/LoxP, shRNAs, and more, require days to achieve protein depletion. This will lead to the concern of the secondary eff...
ORGANISM(S): Homo sapiens (Human) 
2026-08-24 | PXD060834 | Pride
Lc-msms 
ProteomicsAn rRNA fragment in extracellular vesicles secreted by human airway epithelial cells increases the fluoroquinolone sensitivity of P. aeruginosa
Extracellular vesicles (EVs) secreted by human airway epithelial cells contain small RNAs that are transferred to P. aeruginosa upon EV exposure. The purpose of this experiment was to characterize the effect of a 27-nucleotide long human 18S rRNA external transcribed spacer fragment on P. aeruginosa...
ORGANISM(S): Pseudomonas aeruginosa (strain UCBPP-PA14) 
2023-10-24 | PXD033165 | Pride
Airway cells Pseudomonas aeruginosa Evs Host-pathogen communication 
ProteomicsExtracellular Particles Derived from Mesenchymal Stromal Cells Reduce Pseudomonas aeruginosa Lung Infection and Inflammation in Mice
The World Health Organization and the U.S. Centers for Disease Control and Prevention have reported that antibiotic resistant infections with Pseudomonas aeruginosa present a significant health risk world-wide. In the genetic disease Cystic Fibrosis (CF), chronic antibiotic resistant Pseudomonas lun...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD070855 | Pride
Mesenchymal stromal cells Extracellular particles Lung disease Antibiotic resistance Inflammation Pseudomonas aeruginosa Cystic fibrosis 
ProteomicsAn antibody biomarker associated with Onchocerca volvulus microfilariae identified by proteomics of parasite tissue isolated by laser capture microdissection
Onchocerciasis (river blindness), a neglected tropical disease caused by the filarial nematode Onchocerca volvulus, impacts millions of people in sub-Saharan Africa. The World Health Organization coordinates global efforts to eliminate onchocerciasis and has prioritized development of improved diagn...
ORGANISM(S): Homo sapiens (Human) Onchocerca sp. NP-2011 
2026-07-27 | PXD057556 | Pride
Lc-ms/ms Laser capture microdissection 
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