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ProteomicsMass spectrometric analysis of chondroitin sulfate-linked peptides
Chondroitin sulfate proteoglycans are integral components of the extracellular matrix. These are composed of repeating disaccharide units of glucuronic acid and N-acetylgalactosamine linked to a serine residue on the core protein through an oligosaccharide linker. The functions of chondroitin sulfat...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD029400 | Pride
Human Urine Chondroitin-sulfate linked peptides Plasma Proteoglycans Fibroblasts Lc-ms/ms 
TranscriptomicsDermatan sulfate is involved in the tumorigenic properties of Esophagus Squamous Cell Carcinoma
Extracellular matrix, either produced by cancer cells or by cancer-associated fibroblasts, influences angiogenesis, invasion and metastasis. Chondroitin/dermatan sulfate (CS/DS) proteoglycans, which occur both in the matrix and at the cell surface, play important roles in these processes. The unique...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-27040 | biostudies-arrayexpress
ProteomicsIdentification of a chondroitin sulfate linkage region trisaccharide
Here, using LC-MS/MS, we describe for the first time a linkage region trisaccharide comprising [-GlcUA-Gal-Xyl-O-] as an alternative point of entry for glycosaminoglycan (GAG) biosynthesis. The trisaccharide was identified in the proteoglycan bikunin from urine of human healthy donors present as a d...
ORGANISM(S): Homo sapiens (Human) 
2019-02-25 | PXD011855 | Pride
Glycosaminoglycan Lc-ms Chondroitin sulfate Hcd Negative ionisation mode Orbitrap Bikunin 
TranscriptomicsThe metabolic niche of a prominent sulfate-reducing human gut bacterium [3]
Sulfate-reducing bacteria (SRB) colonize the guts of ~50% of humans. We used genome-wide transposon mutagenesis and insertion-site sequencing (INSeq), RNA-Seq, plus mass spectrometry to characterize genetic and environmental factors that impact the niche of Desulfovibrio piger, the most common SRB i...
ORGANISM(S): Mus musculus 
2013-07-12 | E-GEOD-48808 | biostudies-arrayexpress
ProteomicsLC-MS/MS analysis of I?I proteoglycopeptides
The inter-alpha-trypsin inhibitor (I?I) complex is a macromolecular arrangement of structurally related heavy chain proteins covalently cross-linked to the chondroitin sulfate (CS) chain of the proteoglycan bikunin. The I?I complex is abundant in plasma and associated with inflammation, kidney disea...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080725 | MassIVE
TranscriptomicsEMT6 3D CS-E
Mouse EMT6 breast cancer cells were grown in 3D Matrigel culture. Effects of the glycosaminoglycan chondroitin sulfate-E (CS-E) versus untreated controls on transcriptional programs was investigated.
ORGANISM(S): Mus musculus 
2014-08-01 | E-MTAB-2645 | biostudies-arrayexpress
ProteomicsPREDICTIVE MODELING OF THERAPEUTIC RESPONSE TO CHONDROITIN SULFATE/GLUCOSAMINE HYDROCHLORIDE IN KNEE OSTEOARTHRITIS
In the present study we explored potential protein biomarkers useful to predict the therapeutic response of osteoarthritis (OA) patients treated with pharmaceutical grade Chondroitin sulfate/Glucosamine hydrochloride (CS+GH; Droglican, Bioiberica), in order to optimize therapeutic outcomes.
ORGANISM(S): Homo sapiens (Human) 
2019-09-12 | PXD012444 | Pride
Predictive biomarkers Chondroitin sulfate/glucosamine hydrochloride Proteomics Osteoarthritis 
ProteomicsMapping the binding site of VAR2CSA to chondroitin sulfate A
The FPOP was performed in order to map the binding site of chondroitin sulfate A to VAr2CSA from Plasmodium.
ORGANISM(S): Plasmodium falciparum FcB1/Columbia 
2021-04-09 | PXD024154 | Pride
Chondoitin sulfate a Hrpf Var2csa Fpop 
TranscriptomicsTranscription profiling time series of the growth of human IMR-90 cells seeded on a collagen/chondroitin sulfate tissue engineering scaffold
A series of chips with some repeated measurments. Each chip represents a pool of 4 collagen/chondroitin sulfate tissue engineering scaffold meshes seeded with 1 x 10^6 IMR-90 Human Fibroblasts. mRNA was isolated at 30 minutes, 1, 2, 4, 8, 12, 24, 48, and 72 hours after seeding.
ORGANISM(S): Homo sapiens 
2007-12-13 | E-GEOD-409 | biostudies-arrayexpress
ProteomicsMapping the human chondroitin sulfate glycoproteome reveals an unexpected correlation between glycan sulfation and attachment site characteristics
Chondroitin sulfate proteoglycans (CSPGs), an important class of carbohydrate-modified proteins, are composed of chondroitin sulfate (CS) polysaccharide(s) attached to different core proteins. CS polysaccharides interact with a multitude of protein ligands to control key events in homeostasis and de...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD037990 | Pride
Glycosaminoglycans  proteoglycans  glycoproteomics  glycopeptides 
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