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TranscriptomicsSmoking is Associated with Shortened Airway Cilia
Background: Whereas cilia damage and reduced cilia beat frequency have been implicated as causative of reduced mucociliary clearance in smokers, theoretically mucociliary clearance could also be affected by cilia length. Based on models of mucociliary clearance predicting cilia length must exceed th...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-16696 | biostudies-arrayexpress
TranscriptomicsAltered Expression of Intraflagellar Transport Genes is Associated with Short Cilia in Smoking and COPD
Study Smoking and COPD are associated with decreased mucociliary clearance and healthy smokers have shorter cilia in the large airway than nonsmokers. Intraflagellar transport (IFT) is the process by which cilia are produced and maintained. We assessed expression of IFT-related genes in smokers and ...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-43939 | biostudies-arrayexpress
ProteomicsDSSO Crosslinking of Intact Tetrahymena Thermophila Cilia
The MS-cleavable crosslinker, DSSO, was added to cilia isolated from Tetrahymena thermophila. After digestion crosslinked peptides were enriched by size exclusion chromatography. Data were collected using an MS2/MS3 method. Analysis was done using the XlinkX node of PD2.3 and a fasta file generat...
ORGANISM(S): Tetrahymena Thermophila (ncbitaxon:5911) 
2022-07-19 | MSV000089917 | MassIVE
ProteomicsProteome expression profile of primary cilia deficient mIMCD3 cells
We characterized the protein expression profiles in ciliated kidney tubular epithelial cells and studied the changes upon loss of primary cilia.
ORGANISM(S): Mus musculus (Mouse) 
2022-12-07 | PXD035290 | Pride
Cilia Autophagy Ripk3 Ciliopathies Nphp Kidney Necroptosis 
ProteomicsQuantitative phosphoproteomic analysis of the effect of deletion and duplication of the 16p11.2 genomic locus on induced pluripotent stem cells-derived neural progenitor cells
Deletion and duplication of the 16p11.2 genomic locus are associated with opposing changes in brain size. To determine cellular mechanisms that might underlie these opposing phenotypes, we performed quantitative phosphoproteomics on induced pluripotent stem cells (iPSC) derived neural progenitor cel...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD066614 | Pride
Taok2 Phosphorylation Neural progenitor cells Cilia length 
UnknownDevelopment of a method for the measurement of primary cilia length in 3D.
Not available
S-EPMC3555708 | biostudies-literature
ProteomicsWT and FAP256-KO Cilia Proteome from Tetrahymena thermophila
Cilia are essential organelles that protrude from the cell body. Cilia are made of a microtubule-based structure called the axoneme. In most types of cilia, the ciliary tip is distinct from the rest of the cilium. By analysing Tetrahymena thermophila cells lacking a ciliary tip-enriched protein CEP1...
ORGANISM(S): Tetrahymena thermophila CU428 
2023-09-01 | PXD042582 | Pride
Cu428 Cep104 Fap256 Cilia Tetrahymena 
UnknownMI-181 Modulates Cilia Length and Restores Cilia Length in Cells with Defective Shortened Cilia.
Not available
S-EPMC11334112 | biostudies-literature
UnknownNew software for automated cilia detection in cells (ACDC).
Not available
S-EPMC6670212 | biostudies-literature
UnknownLF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena.
Not available
S-EPMC6682161 | biostudies-literature
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