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ProteomicsLigand-dependent spatiotemporal signaling profiles of the mu-opioid receptor are controlled by distinct protein-protein interaction networks
Ligand-dependent differences in the regulation and internalization of the mu-opioid receptor (MOR) have been linked to the degree of severity of the side effects that limit the use of opiates in the treatment of pain. For example, activation of the MOR by morphine and DAMGO ([D-Ala2,N-MePhe4,Gly-ol]...
ORGANISM(S): Homo sapiens (Human) 
2019-09-26 | PXD013328 | Pride
Proteomics Ras‐related c3 botulinum toxin substrate 1 (rac1) Extracellular signal regulated kinase (erk) Desmosome G protein-coupled receptor (gpcr) Cell compartmentalization Protein complex Opioid 
ProteomicsHEK293 femtomolar GPCR signaling
G protein-coupled receptors (GPCRs) are the largest class of cell surface signaling proteins; they participate in all physiological processes and are the targets of 30% of marketed drugs. Typically, nanomolar-micromolar concentrations of ligand are used to activate GPCRs in experimental systems. How...
ORGANISM(S): Homo sapiens (Human) 
2018-10-11 | PXD011033 | Pride
Compartmentalized signaling Femtomolar Camp B2ar M3r Signaling complex Gpcr Highly sensitive Ultra-low 
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