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ProteomicsIsotopic-labelled Clickable Glutathione to Quantify Protein S-Glutathionylation
Investigated protein glutathionylation in HL-1 cardiomyocyte cells in response to hydrogen peroxide using a clickable glutathione approach. After exposure, or not, to hydrogen peroxide the glutathionylated proteins with heavy or light azido glutathione were enriched and subjected to LC-MS/MS analysi...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD014937 | Pride
Clickable glutathione Glutathionylation Cardiomyocyte 
ProteomicsClickable Glutathione Approach for Identification of Protein Glutathionylation in Response to Glucose Metabolism
Glucose metabolism and mitochondrial function are closely interconnected with cellular redox-homeostasis. Although glucose starvation, which often occurs in ischemic heart or insufficient vascularization of tumor cells, is known to induce redox-disturbance, global and individual protein glutathionyl...
ORGANISM(S): Homo sapiens (Human) 
2018-10-26 | PXD004026 | Pride
Glutathionylation 
ProteomicsClickable glutathione-based Isotope Coded Affinity Label to quantify glutathionylation
Identification of cysteines with high oxidation susceptibility is important for understanding redox-mediated biological processes associated with health and disease. We developed a chemical proteomic strategy that helps find cysteines with high susceptibility to S-glutathionylation. Our strategy is ...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-07 | PXD034976 | Pride
Lc-ms/ms for glutathionylation in mouse c2c12 
UnknownIsotopically Labeled Clickable Glutathione to Quantify Protein S-Glutathionylation.
Not available
S-EPMC7078011 | biostudies-literature
UnknownA clickable glutathione approach for identification of protein glutathionylation in response to glucose metabolism.
Not available
S-EPMC4955733 | biostudies-literature
ProteomicsSite-specific Identification of Glutathionylation
Cardiomyocytes proteins were investigated for their glutathionylation in response to hydrogen peroxide generated from glucose oxidase and using a clickable glutathione derivative. After exposure, or not, to hydrogen peroxide the glutathionylated proteins were enriched and LC-MS/MS analyses was perfo...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-06 | PXD012171 | Pride
Ptm Glutathionylation Affinity purification 
ProteomicsSite-specific Identification and Quantification of Protein Glutathionylation under Ischemic Stress
Ischemia or ischemic reperfusion is well-known for its contribution to heart diseases. During ischemia and reperfusion, a flux of nutrients and oxygen to cardiomyocytes is altered, which causes a burst of ROS from mitochondria and other enzymes. Elevated levels of ROS can cause oxidative modificatio...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-13 | PXD024766 | Pride
Gutathionylation Cardiomyocytes Click chemistry 
ProteomicsPeroxide antimalarial drugs impact redox homeostasis in Plasmodium falciparum infected red blood cells
Plasmodium falciparum causes the most lethal form of malaria. The frontline treatments for this severe disease are combination therapies based on semisynthetic peroxide antimalarials, known as artemisinins. There is growing resistance to artemisinins and new drugs with novel mechanisms of action are...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 
2022-02-17 | PXD027334 | Pride
Plasmodium falciparum Malaria Redox homeostasis Peroxides Glutathione. Ozonides 
UnknownIdentification and Quantification of Glutathionylated Cysteines under Ischemic Stress.
Not available
S-EPMC8751622 | biostudies-literature
UnknownNucleophile-triggered prodrug release from polymer hydrogels.
Not available
S-EPMC12621203 | biostudies-literature
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