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UnknownRecombinant human parainfluenza virus type 2 vaccine candidates containing a 3' genomic promoter mutation and L polymerase mutations are attenuated and protective in non-human primates.
Not available
S-EPMC2040028 | biostudies-literature
UnknownOverall Vertical Transmission of Hepatitis C Virus, Transmission Net of Clearance, and Timing of Transmission.
Not available
S-EPMC9989130 | biostudies-literature
ProteomicsRegulation of CHK1 inhibitor resistance by a c-Rel and USP1 dependent pathway C4PR_LIV
The ATR-CHK1 signalling pathway responds to single strand DNA breaks and is required for cancer cells to survive the high levels of DNA replication stress and genomic instability resulting from the activity of oncogenes such as MYC. For this reason, inhibitors of CHK1 have great potential as anti-c...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-19 | PXD026203 | Pride
Sps-ms3 Mouse Tmt Phosphorylation Lc-ms/ms 
UnknownRecombinant newcastle disease virus expressing a foreign viral antigen is attenuated and highly immunogenic in primates.
Not available
S-EPMC1262603 | biostudies-literature
ProteomicsDisplacement of PKA catalytic subunit from AKAP signaling islands drives pathology in Cushing’s syndrome C4PR_LIV
Mutations in the catalytic subunit of protein kinase A (PKAc) drive the stress hormone disorder adrenal Cushing’s syndrome. We define mechanisms of action for the PKAcL205R and W196R variants. Proximity proteomic techniques demonstrate that both Cushing’s mutants are excluded from A kinase anchoring...
ORGANISM(S): Homo sapiens (Human) 
2022-07-12 | PXD030888 | Pride
Cortisol Proximity biotinylation Prkaca Scaffold Stress hormone Anchoring Signaling Photoactivation Adrenal 
ProteomicsDiscovery of a new Cushing’s syndrome PKAc mutant that is retained within anchored type I holoenzymes
Adrenal Cushing’s syndrome is a disease of cortisol hypersecretion often caused by mutations in protein kinase A catalytic subunit (PKAc). Using a personalized medicine screening platform, we discovered a new Cushing’s driver mutation, PKAc-W196G, in ~20% of patient samples analyzed. Proximity prote...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2024-02-10 | PXD045556 | Pride
Cushing's syndrome Pka 
UnknownReproductive inequality in humans and other mammals.
Not available
S-EPMC10235947 | biostudies-literature
UnknownPrespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT).
Not available
S-EPMC4898313 | biostudies-literature
UnknownStratified analyses refine association between TLR7 rare variants and severe COVID-19.
Not available
S-EPMC11320601 | biostudies-literature
UnknownReduced lung-cancer mortality with low-dose computed tomographic screening.
Not available
S-EPMC4356534 | biostudies-literature
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