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TranscriptomicsRiboSeq of BSR cells infected at MOI 3 with Theiler's murine encephalomyelitis virus, compared to mock-infected controls, harvested at 10 hpi
BSR cells were infected with the Cardiovirus B archetype, Theiler’s murine encephalomyelitis virus (TMEV), and mutants thereof, and subjected to ribosome profiling to analyse the viral translatome, frameshifting, and ribosome pausing events. Samples were harvested at 10 hpi by flash-freezing, withou...
ORGANISM(S): Mesocricetus auratus 
2021-11-10 | E-MTAB-9438 | biostudies-arrayexpress
TranscriptomicsModulation of murine bone marrow derived dendritic cells by IL-4
The archetypal Th2 cytokine interleukin 4 (IL-4) has previously been shown to alternatively activate dendritic cells (DCs) both in vitro and in vivo.To more fully understand the impact of IL-4 dependent alternative activation of DCs, we used mRNA microarrays to define their transcriptional profile. ...
ORGANISM(S): Mus musculus 
2015-04-28 | E-GEOD-59868 | biostudies-arrayexpress
UnknownUS Intergroup Trial of Response-Adapted Therapy for Stage III to IV Hodgkin Lymphoma Using Early Interim Fluorodeoxyglucose-Positron Emission Tomography Imaging: Southwest Oncology Group S0816.
Not available
S-EPMC4966513 | biostudies-literature
ProteomicsRapid Highly-Efficient Digestion and Peptide Mapping of Adeno-Associated Viruses
[15:18] Toole, Estee Adeno-Associated Viruses (AAVs) comprise an area of rapidly growing interest due to their ability to act as a gene delivery vehicle in novel gene therapy strategies and vaccine development. Peptide mapping is a common technique in the biopharmaceutical industry to confirm ...
ORGANISM(S): Adeno-associated virus - 2 
2022-02-17 | PXD025971 | Pride
Viral therapies Pepsin Trypsin [15:18] toole Aav Peptide mapping Proteolysis Nanolc Estee gene therapy 
TranscriptomicsRibosome profiling of MARC-145 or MA-104 cells infected with porcine reproductive and respiratory syndrome virus (PRRSV)-1 or PRRSV-2, harvested at 3-12 hpi
Cell lines derived from Chlorocebus sabaeus kidney were infected with an isolate of PRRSV-1 or PRRSV-2 and ribosome profiling was performed (this entry) in parallel with RNASeq (see related accession number). These datasets were used to analyse the viral and host translatome, frameshifting on the vi...
ORGANISM(S): Chlorocebus sabaeus 
2022-03-09 | E-MTAB-10621 | biostudies-arrayexpress
TranscriptomicsPaired-end ribosome profiling of MARC-145 cells infected with porcine reproductive and respiratory syndrome virus (PRRSV)-2, harvested at 9 hpi
MARC-145 cells were infected with porcine reproductive and respiratory syndrome virus (PRRSV)-2 isolate SD95-21 (KC469618.1), and a mutant thereof (KO2), and subjected to ribosome profiling to analyse the viral and host translatome, frameshifting on the viral genome, and putative frameshift-related ...
ORGANISM(S): Chlorocebus sabaeus 
2022-03-09 | E-MTAB-10622 | biostudies-arrayexpress
TranscriptomicsRNASeq of MARC-145 or MA-104 cells infected with porcine reproductive and respiratory syndrome virus (PRRSV)-1 or PRRSV-2, harvested at 3-12 hpi
Cell lines derived from Chlorocebus sabaeus kidney were infected with an isolate of PRRSV-1 or PRRSV-2 and RNASeq was performed (this entry) in parallel with ribosome profiling (see related accession numbers). These RNASeq datasets provide information on the transcriptome of PRRSV-infected cells and...
ORGANISM(S): Chlorocebus sabaeus 
2022-03-09 | E-MTAB-10623 | biostudies-arrayexpress
ProteomicsMechanochemical tuning of a kinesin motor essential for malaria parasite transmission
Kinesins are a superfamily of molecular motors that undertake ATP-dependent microtubule-based movement or regulate microtubule dynamics. Plasmodium species, which cause malaria and kill hundreds of thousands annually, encode ~9 kinesins in their genomes. Of these, two – kinesin-8B and kinesin-8X - a...
ORGANISM(S): Plasmodium berghei ANKA 
2022-12-05 | PXD037474 | Pride
Cryo-em Malaria Microtubule Warwick_rtp Atpase Kinesin Motor Flagella 
GenomicsA dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells [ChIP-Seq]
Dendritic cells (DCs) direct CD4+ T cell differentiation into distinct T helper (Th) subsets that are vital for protection against diverse types of infection. However, the mechanisms employed by DCs to initiate Th2 responses, which are important for immunity to helminth infection as well as being a...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-66198 | biostudies-arrayexpress
TranscriptomicsA Leukemic Stem Cell Expression Signature is Associated with Clinical Outcomes in Acute Myeloid Leukemia
Context: In many cancers, specific subpopulations of cells appear to be uniquely capable of initiating and maintaining tumors. The strongest support for this cancer stem cell model comes from transplantation assays in immune-deficient mice indicating that human acute myeloid leukemia (AML) is organi...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-24006 | biostudies-arrayexpress
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