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MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Xenograft assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS730 | MetaboLights
MetabolomicsAberrant L-Fucose accumulation and increased core fucosylation are metabolic liabilities in mesenchymal glioblastoma (Stem cell and cell line assays)

Glioblastoma (GBM) is a common and deadly form of brain tumor in adults. Dysregulated metabolism in GBM offers an opportunity to deploy metabolic interventions as precise therapeutic strategies. To identify the molecular drivers and the modalities by which different molecular subgroups of GBM exp...

2022-11-08 | MTBLS4708 | MetaboLights
ProteomicsDivide-and-conquer matrisome protein (DC-MaP) strategy: an optimal approach to proteomic matrisome characterization
Currently, the extracellular matrix (ECM) is considered a pivotal complex meshwork of macromolecules playing a plethora of biomolecular functions in health and disease beyond its commonly known mechanical role. Only by unravelling its composition, we can leverage related tissue engineering and pharm...
ORGANISM(S): Homo sapiens (Human) 
2020-12-03 | PXD020823 | Pride
Proteins Identifcation Matrisome Fractionation Human Ovarian 
ProteomicsMouse PSC Q-regulated matrisome
The goal of this project was to assess how glutamine availability regulates the matrisome. ECM deposited by pancreatic stellate cells (PSCs) in the presence of TGFb stimulation under 4, 1, or 0.4mM glutamine (Q) was profiled.
ORGANISM(S): Mus musculus (Mouse) 
2026-04-19 | PXD073686 | Pride
Ecm Psc Matrisome Fibroblast Glutamine 
ProteomicsIn-depth matrisome and glycoproteomic analysis of glioblastoma human brain tissue
Glioblastoma (GBM) is the most common and malignant primary brain tumor. The extracellular matrix (ECM), also known as the matrisome, helps determine glioma invasion, adhesion, and growth. Little attention, however, has been paid to glycosylation of the ECM components that constitute the majority of...
ORGANISM(S): Homo sapiens (Human) 
2022-04-04 | PXD028931 | Pride
Glycosylation Proteomics Chondroitin sulfate Glycoproteins Glycosaminoglycans Mass-spectrometry Glioblastoma Matrisome Heparan sulfate Proteoglycans Glycomics Extracellular matrix 
ProteomicsMatrisome Proteomics Reveals Novel Mediators of Muscle Remodeling with Aerobic Exercise Training
Skeletal muscle has a unique ability to remodel in response to stimuli such as contraction and aerobic exercise training. Phenotypic changes in muscle that occur with training such as a switch to a more oxidative fiber type, and increased capillary density contribute to the well-known health benefit...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-30 | PXD053003 | Pride
Matrisome-associated Proteomics Skeletal muscle Remodeling Exercise Core matrisome 
UnknownDynamic profiling of BMSC-dECM reveals accumulation of core matrisome proteins suppresses osteogenic differentiation and bone regeneration.
Not available
S-EPMC12869295 | biostudies-literature
ProteomicsSWATH mass spectrometry as a tool for quantitative profiling of the matrisome
Proteomic analysis of extracellular matrix (ECM) and ECM-associated proteins, collectively known as the matrisome, is a challenging task due to its inherent complexity and insolubility. Here we present sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH MS)...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-19 | PXD008651 | Pride
Proteomics Mass spectrometry Dia ms Extracellular matrix Matrisome Swath ms 
UnknownAnalysis of matrisome expression patterns in murine and human dorsal root ganglia.
Not available
S-EPMC10471487 | biostudies-literature
UnknownDivide-and-Conquer Matrisome Protein (DC-MaP) Strategy: An MS-Friendly Approach to Proteomic Matrisome Characterization.
Not available
S-EPMC7730167 | biostudies-literature
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