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GenomicsMacroH2A1 regulates the balance between self-renewal and differentiation commitment in embryonic and adult stem cells
One of the most striking epigenetic alterations that occurs at the level of the nucleosome is the complete exchange of the canonical H2A histones for the macroH2A variant. Here, we provide insight in the function of this unique histone variant in embryonic and adult stem cells. Knockdown of macroH2A...
ORGANISM(S): Mus musculus 
2012-02-20 | E-GEOD-35087 | biostudies-arrayexpress
UnknownFrag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis.
Not available
S-EPMC1172282 | biostudies-literature
TranscriptomicsDownregulation of microRNA expression in the lungs of rats exposed to cigarette smoke
While microRNAs have extensively been investigated in cancer research, little is known regarding their response to noxious agents in apparently healthy tissues. We analyzed the expression of 484 miRNAs in the lung of rats exposed to environmental cigarette smoke (ECS) for 28 days. ECS downregulat...
ORGANISM(S): Rattus sp. 
2010-05-19 | E-GEOD-13260 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression in rat lung receiving chemopreventive agents and attenuation of cigarette smoke-induced alterations
We previously showed that exposure of rats to environmental cigarette smoke (ECS) causes extensive downregulation of microRNA expression in the lung, resulting in overexpression of multiple genes and proteins. In the present study, we evaluated by microarray the expression of 484 microRNAs in the l...
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-19540 | biostudies-arrayexpress
TranscriptomicsExpression and Prognostic impact of LncRNAs in AML
Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides located within the intergenic stretches or overlapping antisense transcripts of protein coding genes. LncRNAs are involved in numerous biological roles including imprinting, epigenetic regulation, apoptosis and cell-cycle. To ...
ORGANISM(S): Homo sapiens 
2014-11-26 | E-GEOD-63614 | biostudies-arrayexpress
TranscriptomicsmiRNA expression in the spleen of C57BL mice, p53-knockout C57BL mice, and NO2-knockout C57BL mice.
The goal of the study is to assess whether inflammation-induced oxidative and nitrosative stress modulates miRNA expression in mouse model deficient in either p53 or NOS2 RNA was extracted from the spleen of C57BL mice (WT, NOS2 knockout, and p53 knockout) that were C. Parvum treated or saline contr...
ORGANISM(S): Mus musculus 
2012-06-17 | E-GEOD-30218 | biostudies-arrayexpress
TranscriptomicsCXCR4/YinYang1/Hsa-let-7a axis functions as tumor suppressor in acute myeloid leukemia
Surface expression of C-X-C chemokine receptor type 4 (CXCR4) in acute myeloid leukemia (AML) has been reported to be an independent prognostic factor for disease relapse and survival. We previously reported that targeting the stromal-derived factor 1M-NM-1 (SDF-1M-NM-1)/CXCR4 axis could overcome re...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-44828 | biostudies-arrayexpress
UnknownLoss of miR-204 expression is a key event in melanoma.
Not available
S-EPMC5844115 | biostudies-literature
ProteomicsSUZ12 immunoprecipitation followed by PRM of SUZ12 peptides to identify alternatively spliced isoforms of SUZ12 at the protein level.
Alternative splicing of SUZ12 exon 4 is predicted to generate two alternative isoforms differing by the inclusion or exclusion of 69 nucleotides in exon 4, which we named SUZ12-long (SUZ12-L) and SUZ12-short (SUZ12-S) respectively. At the protein level SUZ12 exon 4 encodes 23 amino acids (aa 129–152...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-18 | PXD046742 | Pride
Exon As Ip Prc2 Mescs Alternative splicing Prm. Escs Suz12 Polycomb 
ProteomicsSUZ12 immunoprecipitation followed by protein indentification via mass spectrometry (SUZ12 IP-MS) in mESCs of SUZ12 WT, delta exon 4, KO, and KO rescues with SUZ12-L and SUZ12-S
Suz12 exon 4 encodes 23 amino acids (aa 129–152 in SUZ12-L) that partially overlap with the WD-binding domain 1 (WDB1, 110–145). We reasoned that exon 4 skipping might alter the structure of SUZ12 and, possibly, PRC2 composition. To explore this possibility, we generated ESCs that lack the Suz12 exo...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-18 | PXD046660 | Pride
Flag-tag Rescues Ko Ip Prc2 Interactions Mescs Escs Suz12 Polycomb 
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