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UnknownXPG is a novel biomarker of clinical outcome in advanced non-small-cell lung cancer.
Not available
S-EPMC3809298 | biostudies-literature
TranscriptomicsGenome-Wide Microarray Analysis of Histone H2B Ubiquitylation mutant strains of Tetrahymena thermophila
Microarray analyses were performed to compare the gene expression profiles of wild-type and several mutant strains of the ciliated protozoan Tetrahymena thermophila. Elimination of H3K4 methylation (hht2-K4Q) and knockout of either of the ubiquitylation enzymes (delta-UBC2 and delta-BRE1) affects a ...
ORGANISM(S): Tetrahymena thermophila 
2010-06-20 | E-GEOD-18743 | biostudies-arrayexpress
ProteomicsTriptolide clears Staphylococcus aureus infection by targeting XIAP to induce host apoptosis while preserving gut microbiota homeostasis [Mouse lung macrophages]
Staphylococcus aureus (SA) remains a global health threat due to its increasing drug resistance and intracellular persistence, which compromise the efficacy of conventional antibiotics. Host-directed therapy (HDT) has emerged as a promising alternative by modulating host immunity. With the multi-tar...
ORGANISM(S): Mus musculus (Mouse) Staphylococcus aureus 
2026-05-18 | PXD074740 | Pride
Triptolide Microbiota homeostasis Host-directed therapy Methicillin-resistant staphylococcus aureus Apoptosis Xiap Staphylococcus aureus 
ProteomicsA bacterial effector manipulates host lysosomal protease activity-dependent plasticity in cell death modalities to facilitate infection
Crosstalk between cell death programs confers appropriate host anti-infection immune responses, but how pathogens remodel this network to facilitate their infections remain largely unclear. Here, we identify mammalian cell entry 3C (Mce3C) as a key regulator of host cell death from Mycobacterium tub...
ORGANISM(S): Homo sapiens (Human) Mycobacterium tuberculosis 
2025-01-27 | PXD041707 | Pride
Mycobacteria tuberculosis Secreated protein Mce3c 
ProteomicsPathogenic phosphorylation of linear ubiquitin machinery causes inflammasome sensor degradation [Mouse]
Mass spectrometry analysis of phosphorylated sites in mouse HOIL-1L modified by PknG upon Mtb infection in iBMDMs.
ORGANISM(S): Mus musculus (Mouse) 
2025-08-08 | PXD064141 | Pride
Mycobacterium tuberculosis Hoil-1l Pkng 
ProteomicsPathogenic phosphorylation of linear ubiquitin machinery causes inflammasome sensor degradation [Human]
Mass spectrometry for analysis of phosphorylation sites in human HOIL-1L modified by Mycobacterium tuberculosis PknG.
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD046319 | Pride
Pkng Mycobacterium tuberculosis Hoil-1l Nlrp3 inflammasome Lubac 
MetabolomicsMicrobiome and metabolome features in inflammatory bowel disease via multi-omics integration analyses across cohorts

The perturbations of the gut microbiota and metabolites are closely associated with the progression of inflammatory bowel disease (IBD). However, inconsistent findings across studies impede a comprehensive understanding of their roles in IBD and their potential as reliable diagnostic biomarkers. ...

2026-01-28 | MTBLS8713 | MetaboLights
Proteomicsphotoactivation-dependent proximity labeling (PDPL) MS
we report a photoactivation-dependent proximity labeling (PDPL) method designed by genetically attaching photosensitizer protein miniSOG to a protein of interest (POI). Triggered by blue light, singlet oxygen is generated, enabling temporally-resolved chemical probe labeling.
ORGANISM(S): Homo Sapiens 
2022-06-22 | PXD034811 |
ProteomicsThe mechanism of TRIM21 inhibiting the invasion and migration of ccRCC by stabilizing ASS1
Clear cell renal cell carcinoma (ccRCC) is characterized by its aggressive invasion and metastasis, posing significant clinical challenges. Understanding the molecular mechanisms underlying its progression is crucial for developing effective therapeutic strategies. The role of TRIM21 in regulating A...
ORGANISM(S): Homo Sapiens 
2024-08-13 | PXD054847 |
ProteomicsProteomics analysis of human amniotic epithelial cell-derived extracellular vesicles
Proteomics analysis of human amniotic epithelial cell-derived extracellular vesicles.
ORGANISM(S): Homo Sapiens 
2021-12-07 | PXD030221 |
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