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ProteomicsSCFCyclin F targets the metabolic protein Sirtuin 5 for ubiquitination
Cell cycle transitions are regulated by a number of coordinating signaling events. The ubiquitin-proteasome system is an important part of this cell cycle signaling. Cyclin F, a substrate adapter for the SCF (SKP1/CUL1/F-box) E3 ubiquitin ligase, is an important regulator of cell cycle progression. ...
ORGANISM(S): Homo Sapiens (human) 
2020-11-17 | PXD019396 | JPOST Repository
Proteomicsβ-TrCP and Casein Kinase II mediated degradation of cyclin F controls timely mitotic progression
Orderly progressions of events in the cell division cycle are necessary to ensure the replication of DNA and cell division. Checkpoint systems allow the accurate execution of each cell cycle phase. The precise regulation of the levels of cyclin proteins is fundamental to coordinate cell division w...
ORGANISM(S): Homo sapiens (Human) 
2018-10-02 | PXD010737 | Pride
Mitotic progression Ck2 Cyclin f 
ProteomicsCyclin F - EXO1 axis controls cell cycle dependent execution of double strand break repair
Ubiquitination is a crucial post-translational modification required for the proper repair of DNA double-strand breaks (DSBs) induced by ionising radiation (IR). DSBs are mainly repaired through homologous recombination (HR) when template DNA is present and non-homologous end joining (NHEJ) in its a...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD051841 | Pride
Microhomology-mediated end joining And cancer Ionising radiation Dna damage repair Dna damage response Dna double strand breaks Exo1 Ubiquitination Single strand annealing Cell cycle Cyclin f 
ProteomicsIdentification of CCNF/Cyclin F targets
The founding member of the F-box protein family, Cyclin F, serves as substrate adaptor for the Ubiquitin E3 ligase Skp1-Cul1-F-box (SCF)Cyclin F which is responsible for ubiquitination of proteins involved in cell cycle progression, DNA damage and mitotic fidelity. Missense mutations in CCNF encodin...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2022-09-13 | PXD030729 | Pride
Lc-ms Human Als Mouse Ccnf Cyclin f 
ProteomicsPhosphorylation of Cyclin F at Serine 621 regulates the Lys48-ubiquitylation E3 ligase activity of the SCF(Cyclin F) complex.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder that is characterized by progressive weakness, paralysis and cachexia often resulting in patient death within 3-5 years of diagnosis. Recently, we identified mutations to the CCNF gene, which encodes the Cyclin F protein, in c...
ORGANISM(S): Homo sapiens (Human) 
2017-12-08 | PXD004531 | Pride
Als Phosphorylation Ubiquitylation E3 ligase 
ProteomicsALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ
Recently, we identified missense mutations in CCNF that are causative of familial and sporadic amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). CCNF encodes for cyclin F, a substrate recognition component of an E3-ubiquitin ligase. Mutations in CCNF directly implicates disrupti...
ORGANISM(S): Homo sapiens (Human) 
2021-03-18 | PXD014163 | Pride
Bioid Ubiquitylation Proteomics Amyotrophic lateral sclerosis Frontotemporal dementia Paraspeckles Cyclin f Rbm14 Homeostasis 
TranscriptomicsComparison of Normal Prostate Fibroblasts Overexpressing Cyclin D1 and Carcinoma Associated Fibroblasts
The cyclin D1 oncogene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the Rb protein and promotes progression through G1 to S phase of the cell cycle. Several prostate cancer cell lines and a subset of primary prostate cancer samples have increased cyclin D1 prote...
ORGANISM(S): Homo sapiens 
2007-08-31 | E-GEOD-6936 | biostudies-arrayexpress
GenomicsGene expression changes after depletion of Cyclin F and atypical E2Fs in HeLa cells.
Gene expression changes after depletion of Cyclin F and atypical E2Fs in HeLa cells.
PRJNA551429 | ENA
ProteomicsTargeting G1–S Checkpoint–Compromised Cancers with Cyclin A/B RxL Inhibitors
Cancer cell proliferation requires precise control of E2F1 activity; excess activity promotes apoptosis. Here, we developed cell-permeable and bioavailable macrocycles that selectively kill small cell lung cancer (SCLC) cells with inherent high E2F1 activity by blocking RxL-mediated interactions of ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-30 | PXD055112 | Pride
Macrocycle Cyclin a E2f Cyclin b Cy/rxl motif Cdk2 Sac Synthetic lethality 
TranscriptomicsGene expression changes after depletion of Cyclin F and atypical E2Fs in HeLa cells.
Using RNAi technology, Cyclin F, E2F7+8, or the combination of all proteins in were knocked down HeLa cells. The goal was to study which gene expression programmes are altered by cyclin F depletion in G2/M cells. Furthermore, we had performed experiments suggesting that cyclin F mediates degradation...
ORGANISM(S): Homo sapiens 
2019-08-29 | GSE133416 | GEO
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