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ProteomicsCYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge
CYRI proteins promote lamellipodial dynamics by opposing Rac1-mediated activation of the Scar/WAVE complex. This activity also supports resolution of macropinocytic cups, promoting internalisation of surface proteins, including integrins. Here, we show that CYRI-B also promotes focal adhesion matu...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD062975 | Pride
Vinculin Bio-id Integrins Actin cytoskeleton Erc1 Focal adhesions Paxillin Cyri-b Microtubules 
UnknownStructural Basis of CYRI-B Direct Competition with Scar/WAVE Complex for Rac1.
Not available
S-EPMC7955166 | biostudies-literature
UnknownStructure of CYRI-B (FAM49B), a key regulator of cellular actin assembly.
Not available
S-EPMC7543656 | biostudies-literature
UnknownCYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake.
Not available
S-EPMC11219039 | biostudies-literature
UnknownCYRI-B loss promotes enlarged mature focal adhesions and restricts microtubule and ERC1 access to the cell leading edge.
Not available
S-EPMC12718634 | biostudies-literature
UnknownCYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation.
Not available
S-EPMC8236918 | biostudies-literature
TranscriptomicsFAM49B suppresses ovarian cancer cell growth through regulating MAPK signaling
The family with sequence similarity 49 member B (FAM49B, also known as CYRI-B) has recently attracted interest as a new player in cancer development. Upregulation of FAM49B expression has been observed in ovarian cancer tissues. Here we show that knockdown of FAM49B significantly increased ovarian c...
ORGANISM(S): Homo sapiens 
2025-12-02 | GSE290202 | GEO
TranscriptomicsRNA-seq experiment of human microglia cell line comparing wild-type control to FAM49B-knockout
FAM49B is a genetic risk factor for Parkinson's disease and plays an important role in immune cells. Our data indicates that FAM49B is specifically expressed in nigral microglia and downregulated with age.
ORGANISM(S): Homo sapiens 
2026-01-14 | E-MTAB-15277 | biostudies-arrayexpress
UnknownCharacterization and Functional Study of FAM49B Reveals Its Effect on Cell Proliferation in HEK293T Cells.
Not available
S-EPMC8872254 | biostudies-literature
UnknownFAM49B suppresses ovarian cancer cell growth through regulating MAPK signaling.
Not available
S-EPMC12531276 | biostudies-literature
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