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ProteomicsPlasmepsin X activates function of the PCRCR complex in P. falciparum by processing PfRh5 for binding to basigin and invasion of human erythrocytes
Plasmodium falciparum causes the most severe form of malaria in humans. The protozoan parasite develops within erythrocytes to mature schizonts, that contain more than 16 merozoites, which egress and invade fresh erythrocytes. The aspartic protease plasmepsin X (PMX), processes proteins and protease...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2023-04-05 | PXD039646 | Pride
Malaria Plasmepsin x Ip-ms Pcrcr 
ProteomicsCaspase-2 protects against ferroptotic cell death
To identify proteins that interact with caspase-2 that could potentially explain its ability to regulate ferroptosis, we performed an unbiased BioID proteomics screen.
ORGANISM(S): Homo sapiens (Human) 
2024-03-06 | PXD041339 | Pride
Caspase-2  ferroptosis  mutant-p53  chaperone mediated autophagy 
ProteomicsTGFB1 induced S100 family protein expression is associated with epithelial to mesenchymal transition states and poor survival in pancreatic cancer
Epithelial-mesenchymal transition (EMT) is a continuum that includes epithelial, partial EMT (P-EMT) and mesenchymal states, each of which are associated with cancer progression, invasive capabilities and ultimately metastasis. We have employed a lineage traced sporadic model of pancreatic cancer to...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-24 | PXD030992 | Pride
Pancreatic cancer Emt S100 
ProteomicsPROTEOMIC ANALYSIS OF EXTRACELLULAR VESICLES FROM RHEUMATOID ARTHRITIS SYNOVIAL FLUID
Previously, extracellular vesicles (EVs) from rheumatoid arthritis (RA) synovial fluid (SF) have been reported to stimulate the release of pro-inflammatory mediators in recipient cells. However, mechanistic details are unclear and contaminants in EV enrichments might have compromised previous obser...
ORGANISM(S): Homo sapiens (Human) 
2021-04-01 | PXD015145 | Pride
Extracellular vesicles Label-free ms Rheumatoid arthritis 
ProteomicsFunction of the Rh5 complex in invasion of human erythrocytes
The most severe form of malaria is caused by Plasmodium falciparum. These parasites invade human erythrocytes and an essential step in this process involves the ligand PfRh5, which forms a complex with CyRPA and PfRipr (RCR complex) and binds basigin on the host cell. We identified a heteromeric dis...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-12-14 | PXD036746 | Pride
Pfripr Basigin Ptramp Human erythrocytes Invasion complex Pfrh5 Malaria Css P. falciparum 
ProteomicsFunctional characterisation of components in two Plasmodium falciparum Cullin-RING-Ligase complexes
Ubiquitination is the key eukaryotic post-translational modification that governs protein degradation, localisation, and activity which is mediated by a concerted enzyme cascade. The largest superfamily of these enzymes include the Cullin-RING-Ligase (CRL) complexes. Plasmodium falciparum, the causa...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2026-01-09 | PXD072749 | Pride
ProteomicsMARCH1 ubiquitination of MHC II generates a branched K63/K11 ubiquitin chain.
Major histocompatibility class II (MHC II) is critical for adaptive immunity. MHC II intracellular trafficking and degradation is regulated by ubiquitination, with poly-ubiquitination (Ub) of MHC II directing it away from the plasma membrane. The MHC II poly-Ub chain that dictates the fate and funct...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-01 | PXD063057 | Pride
Ubiquitin Mhcii Ub-code Aqua peptides 
ProteomicsNK cell-derived GM-CSF is critical for enhancing pathological arthritis
GM-CSF is involved in immune complex (IC)-mediated arthritis. However, little is known about what is the cellular source of GM-CSF and how it is regulated during IC-mediated inflammation. Using novel GM-CSF reporter mice, we show that NK cells produce GM-CSF during an IC-mediated model of inflammato...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-19 | PXD012794 | Pride
Nk cells Arthritis Neutrophils Gm-csf 
ProteomicsSperm-specific proteins and cancer testis antigens exist outside the blood-testis barrier
Sperm develop in the seminiferous tubules of the testis from puberty, sequestered inside the blood-testis barrier to prevent their recognition as “non-self” by the immune system. It is widely assumed that proteins expressed specifically in sperm do not have direct access to the circulation or the im...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-04-01 | PXD014333 | Pride
Testicular interstitial fluid Cancer-testis antigens Germ cell proteins 
ProteomicsEndoplasmic Reticulum Chaperones Stabilize Ligand-Receptive MR1 molecules for Efficient Presentation of Metabolite Antigens
Quantitative MS analysis of MR1 GFP immunoprecipates to identify steady-state binding partnets.
ORGANISM(S): Homo sapiens (Human) 
2020-09-16 | PXD014585 | Pride
Mr1 Mait cells Mhc Label-free ms 
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