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ProteomicsKetogenic diet modifies ribosomal protein dysregulation in KMT2D Kabuki Syndrome
Kabuki syndrome (KS) is a genetic disorder caused by DNA mutations in KMT2D, a lysine methyltransferase that methylates histones and other proteins, and therefore modifies chromatin structure and subsequent gene expression. Ketones, derived from the ketogenic diet, are histone deacetylase inhibitors...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050547 | Pride
Neurodevelopment Tmtpro Butyrate Hydrophilic interaction liquid chromatography Single-cell rna sequencing Lysine methyltransferase Epigenetic Tandem mass tag 
ProteomicsProteomic and phosphoproteomics analysis of triple combination therapy in cystic fibrosis
Trikafta, a CFTR modulator, is increasingly used to treat children with cystic fibrosis (CF), but its effects remain unclear. This study evaluated the cellular mechanisms of Trikafta in young children (< 11 years) with CF using a multi-omic approach. Seventeen children with CF (median age 8.4 years,...
ORGANISM(S): Homo sapiens (Human) 
2026-08-03 | PXD060637 | Pride
Therapeutics Drug Cystic fibrosis Phosphorylation 
ProteomicsProteomics and phosphoproteomics of medicinal cannabis plant extract (NTI164) treatment of paediatric acute-onset neuropsychiatric syndrome
Paediatric acute-onset neuropsychiatric Syndrome (PANS) is a syndrome of infection-provoked abrupt-onset obsessive-compulsive disorder (OCD) or eating restriction. This open-label trial investigated the safety and efficacy of NTI164, a cannabis-derived medicinal formulation rich in cannabinoids (min...
ORGANISM(S): Homo sapiens (Human) 
2026-03-16 | PXD064184 | Pride
Epigenetics Multi-omics Qe plus Immune Tmt Ribosome Cannabis Pans Translation 
TranscriptomicsTranscriptomes of isolated rice gametes characterized by deep sequencing: Evidence for distinct sex-dependent chromatin and epigenetic states before fertilization
The formation of a zygote by the fusion of egg and sperm involves the two gametic transcriptomes. In flowering plants, the embryo sac embedded within the ovule contains the egg cell, while the pollen grain contains two sperm cells inside a supporting vegetative cell. The difficulties of collecting ...
ORGANISM(S): Oryza sativa Japonica Group 
2013-10-31 | E-GEOD-50777 | biostudies-arrayexpress
UnknownImplementation of Recommendations on the Use of Corticosteroids in Severe COVID-19.
Not available
S-EPMC10751594 | biostudies-literature
UnknownCytosponge-trefoil factor 3 versus usual care to identify Barrett's oesophagus in a primary care setting: a multicentre, pragmatic, randomised controlled trial.
Not available
S-EPMC7408501 | biostudies-literature
UnknownCause of Death and Predictors of All-Cause Mortality in Anticoagulated Patients With Nonvalvular Atrial Fibrillation: Data From ROCKET AF.
Not available
S-EPMC4943233 | biostudies-literature
UnknownTherapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
Not available
S-EPMC8362594 | biostudies-literature
UnknownSex differences in post-acute neurological sequelae of SARS-CoV-2 and symptom resolution in adults after coronavirus disease 2019 hospitalization: an international multi-centre prospective observational study.
Not available
S-EPMC10914448 | biostudies-literature
UnknownThe genetic architecture of the human cerebral cortex.
Not available
S-EPMC7295264 | biostudies-literature
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