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ProteomicsIn-depth proteomic analysis of nasal fluids from patients with chronic rhinosinusitis and nasal polyps by data-independent acqusition
Antibiotics are commonly prescribed to treat chronic rhinosinusitis (CRS). However, the effects of antibiotics on the microbiome and secreted proteome remain unknown in regard to CRS.We analyzed the effects of antibiotics on the nasal secreted proteome inthe context of CRS using data-independent acq...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018960 | Pride
Human Crs Nasal fluids Data independent acqusition 
ProteomicsA comprehensive Proteomic Investigation of Ebf1 Heterozygosity in pro-B lymphocytes utilizing Data Independent Acquisition
Early B cell factor 1 (EBF1) is one of the key transcription factors required for orchestrating B-cell lineage development. Although studies have shown that Ebf1 haploinsufficiency is involved in the development of leukemia, no study has been conducted that characterizes the global effect of Ebf1 he...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-20 | PXD008396 | Pride
Dda Pro-b lymphocyte Dia Prm Transcription factor Ebf1 
ProteomicsNarrow precursor window for DIA-MS enhances protein identification and quantification
Data independent acquistion (DIA) is becoming widely as a method of choice in quantitation proteomics due to its high reproducibility and quantitation accuracy at high-throughput fashion. In this project, we systematically evaluated the effect of the selected precursor mass range for DIA-MS on the p...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-10-01 | PXD026965 | Pride
Arabidopsis Data independent acqusition (dia) Lc-ms/ms 
ProteomicsTemporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells
Reactivation of fetal hemoglobin expression by down-regulation of BCL11A is a promising treatment of -hemoglobinopathies. A detailed understanding of BCL11A-mediated repression of -globin gene (HBG1/2) transcription is lacking, as studies to date used perturbations by shRNA or CRISPR/Cas9 gene editi...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD030307 | Pride
Proteomics Data-independent acqusition Protac Mass spectrometry Bcl11a Hemoglobinopathies 
ProteomicsLongitudinal proteomic profiling discovered early prognostic and surrogate markers in COVID-19
In managing patients with coronavirus disease 2019 (COVID-19), early identification of those at high risk and real-time monitoring of disease progression to severe COVID-19 is a major challenge. We aimed to identify early prognostic protein markers and to discover surrogate protein markers that effe...
ORGANISM(S): Homo sapiens (Human) 
2021-09-10 | PXD023686 | Pride
Covid19 Dia Human Serum 
ProteomicsTissue-specific Proteogenomic Analysis of Plutella xylostella Larval Midgut Using a Multi-algorithm Pipeline
Plutella xylostella is the major cosmopolitan pest of brassica and other crucifer crops, the larval midgut of which is a dynamic organ that interfaces with a divers earray of physiological and toxicological processes. The draft sequence of the P.xylostella genome was recently released, but its annot...
ORGANISM(S): Plutella xylostella (Diamondback moth) (Plutella maculipennis) 
2015-10-12 | PXD002028 | Pride
Plutella xylostella Msms Proteogenomic Proteome 
ProteomicsComparative Proteomic Profiling of Variants SARS-CoV-2 Virus-Like-Particles (VLPs) Incubated Cells
The COVID-19 pandemic is arguably the most important global threat to humankind that the world has seen in the 21st century. Since the initial outbreak of SARS-CoV-2 in 2019, the virus genome is continuously mutating that may affect virus characteristics such as infectivity, transmission, and pathog...
ORGANISM(S): Homo sapiens (Human) 
2023-04-15 | PXD034557 | Pride
Nucleocapsid mutations Sars-cov-2 Virus-like-particle Hek293t cells Data independent acqusition (dia) 
ProteomicsDIA proteomics of OGG1 inhibition in murine model of fibrosis
Interstitial lung diseases such as idiopathic pulmonary fibrosis (IPF) are caused by persistent micro-injuries to alveolar epithelial tissues accompanied by aberrant repair processes. Despite substantial advancement in our understanding of IPF progression, numerous questions remain concerning diseas...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-06 | PXD029625 | Pride
Lung tissue Mus musculus Mass spectrometry Dia-ms Bronchoalveolar lavage fluid Orbitrap 
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