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UnknownPhospho-heavy-labeled-spiketide FAIMS stepped-CV DDA (pHASED) provides real-time phosphoproteomics data to aid in cancer drug selection.
Not available
S-EPMC9762002 | biostudies-literature
ProteomicsDDA-PASEF and diaPASEF acquired HCC1806/HS578T proteomic datasets with deliberate batch effects
We generated two comprehensive large-scale proteomics datasets with deliberate batch effects using the latest parallel accumulation-serial fragmentation in both Data-Dependent and Data-Indepentdent Acquisition modes. This dataset contain a balanced two-class design (cell lines: HCC1806 vs HS578T), a...
ORGANISM(S): Homo sapiens (Human) 
2023-11-21 | PXD041391 | Pride
Dda Pasef Dia Hcc1806 Hs578t Batch effects 
ProteomicsDDA-PASEF and diaPASEF acquired A549/K562 proteomic datasets with deliberate batch effects
We generated two comprehensive large-scale proteomics datasets with deliberate batch effects using the latest parallel accumulation-serial fragmentation in both Data-Dependent and Data-Indepentdent Acquisition modes. This dataset contain a balanced two-class design (cell lines: A549 vs K562), allowi...
ORGANISM(S): Homo sapiens (Human) 
2023-11-21 | PXD041421 | Pride
Dda Pasef Dia K562 A549 Batch effects 
ProteomicsA Comparison of Quantitative Mass Spectrometric Methods for Drug Target Identification by Thermal Proteome Profiling
Benchmarking different LFQ-DIA approaches with traditional TMT-DDA for thermal proteome profiling.
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040173 | Pride
Hybrid library Target deconvolution Data-dependent acquisition (dda) Tandem mass tag (tmt) Thermal proteome profiling (tpp) Acute myeloid leukaemia (aml) Spectral library Data-independent acquisition (dia) 
ProteomicsDeep and fast label-free Dynamic Organellar Mapping - DDA data
The Dynamic Organellar Maps (DOMs) approach combines cell fractionation and shotgun-proteomics for global profiling analysis of protein subcellular localization. Here, we have drastically enhanced the performance of DOMs through data-independent acquisition (DIA) mass spectrometry (MS). DIA-DOMs ach...
ORGANISM(S): Homo sapiens (Human) 
2023-08-25 | PXD034962 | Pride
Dynamic organellar maps Dia Data quality control Data-independent acquisition mass spectrometry Spatial proteomics Profiling analysis 
ProteomicsIdentification of TNFRSC (TNF receptor signalling complex) members in DDA
TNFR signalling complex (TNFRSC) pulldown and DDA analysis with 2 controls (HIS_TNFalpha, Unstimulated)
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD019837 | Pride
Dda tnf pulldown 
UnknownA comprehensive LFQ benchmark dataset on modern day acquisition strategies in proteomics.
Not available
S-EPMC8967878 | biostudies-literature
Proteomicsα7 Nicotinic Acetylcholine Receptor-Associated Signaling in U87MG Glioblastoma Cells (LFQ, Orbitrap Elite)
This project investigates the role of α7 nicotinic acetylcholine receptor (α7 nAChR) signaling in glioblastoma using the U87MG human glioblastoma cell line. Cells were treated with selective α7 nAChR ligands (10 μM of agonist PNU282987, 1 μM of positive allosteric modulator PNU120596, 1 μM of antago...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD070911 | Pride
Glioblastoma  u87mg  α7 nicotinic acetylcholine receptor  choline  total proteome  label-free quantification  orbitrap elite  proteomics 
ProteomicsPhospho heavy-labeled-spiketide FAIMS stepped-CV DDA (pHASED) provides real-time phosphoproteomics data to aid in cancer drug selection
Global high-throughput phosphoproteomic profiling is increasingly being applied to cancer specimens as a means to identify the oncogenic signaling cascades responsible for promoting disease initiation and disease progression; pathways that are often invisible to genomics analysis. Hence, phosphoprot...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-24 | PXD037227 | Pride
Cancer Phased Clinical phosphoproteomics Combination therapy Phosphoproteomics Resistance Atm Acute myeloid leukemia Drug targets Oncogenic signaling 
ProteomicsLabel-free quantification (LFQ) analysis of Sphingopyxis granuli TFA wild-type and ΔsuhB strains during exponential and stationary growth phases
A comparative LFQ-based proteomic analysis was performed to assess differences in protein abundance between Sphingopyxis granuli TFA WT and the small RNA mutant ΔsuhB strains during exponential and stationary growth in minimal medium supplemented with 40 mM β-hydroxybutyrate (BHB)
ORGANISM(S): Sphingopyxis granuli Bacteria 
2026-05-18 | PXD073771 | Pride
Proteomics Suhb Small rna Regulon 
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