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ProteomicsThe auophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages
Glucocorticoids are widely used to treat inflammatory disorders; however, prolonged use of glucocorticoids results in side effects including osteoporosis, diabetes and obesity. Compound A (CpdA), identified as a selective NR3C1/glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-11 | PXD012121 | Pride
Autophagy  autophagy receptors  cpda  glucocorticoids  inflammation  nfe2l2/nrf2  sqstm1/p62 
ProteomicsTurboID-based proxisome mapping of the human glucocorticoid receptor in A549 cells
Exogenous glucocorticoids are frequently used to treat inflammatory disorders and as adjuncts in solid cancers. However, their use is associated with severe side effects and therapy resistance. Novel glucocorticoid receptor (GR) ligands with a patient-validated reduced side effect profile have not y...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042014 | Pride
Lc-msms Turboid Glucocorticoid receptor Interactomics 
ProteomicsOptimizing efficacy to safety ratio of glucocorticoids in rheumatoid arthritis models by leveraging PPARα agonism
Glucocorticoids remain essential therapies for immune- and inflammatory diseases such as rheumatoid arthritis (RA) but are notorious for their metabolic side effects. Given the anti-inflammatory and metabolically favorable actions of peroxisome-proliferator activated nuclear receptor (PPAR) agonists...
ORGANISM(S): Homo sapiens (Human) 
2026-09-17 | PXD084343 | Pride
Human Gw7647 Ppar Dexamethasone Glucocorticoid hormones Fibroblast-like synoviocytes 
TranscriptomicsSIN3A-regulated LIF-responsive genes in MCF7 cells
Tyrosine phosphorylation is a hallmark for activation of Signal Transducer and Activator of Transcription (STAT) proteins, but their transcriptional activity also depends on other secondary modifications. Type I interferons (IFNs) can activate both the ISGF3 (STAT1:STAT2:IRF9) complex and STAT3, but...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-35696 | biostudies-arrayexpress
ProteomicsCCR1 inhibition sensitizes multiple myeloma cells to glucocorticoid therapy
One of the cornerstone drugs in the treatment of multiple myeloma (MM) are glucocorticoids. Because MM cells hijack the bone marrow microenvironment to obtain growth and survival signals, resistance to glucocorticoid-induced apoptosis emerges, yet, the underlying mechanisms remain poorly characteriz...
ORGANISM(S): Homo sapiens (Human) 
2025-06-18 | PXD055337 | Pride
Myeloma Glucocorticoids Dexamethasone Ccr1 Bx471 
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