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ProteomicsInteraction-based capture and identification of protein effectors of ppGpp, the master regulator of bacterial growth
The small nucleotide ppGpp is a conserved regulatory molecule in prokaryotes that tunes growth rate in response to nutrient availability. How ppGpp regulates growth remains poorly defined. In Escherichia coli, ppGpp directly binds RNA polymerase to modulate transcription, but it likely has other tar...
ORGANISM(S): Escherichia coli 
2018-10-04 | PXD010402 | Pride
E. coli Ppgpp Lc-ms/ms 
ProteomicsAnalysis of ECM-enriched samples using different methods
Using LC-MS/MS, we analyzed ECM-enriched samples obtained from 1) human triple-negative breast cancer samples and matched adjacent normal mammary gland tissues, and 2) disease-free omentum from patient with non-metastatic ovarian cancer and high-grade- serous-ovarian- cancer-derived omental metastas...
ORGANISM(S): Homo sapiens (Human) 
2017-07-11 | PXD005554 | Pride
Breast cancer Ovarian cancer Ecm Lc-ms/ms 
ProteomicsProteomic characterization of stem cell-derived extracellular matrices
We characterized and compared the proteomic composition of ECM produced in vitro by bone marrow-derived MSC, adipose-derived MSC and neonatal fibroblasts isolated from different donors, employing a multidimensional proteomic approach coupled with label-based quantitative proteomics. Each cell-derive...
ORGANISM(S): Homo sapiens (Human) 
2017-03-08 | PXD005521 | Pride
Lc-ms-ms Human Ecm 
ProteomicsMEIOC interacting proteins during meiotic prophase I
The meiosis-specific chromosomal events of homolog pairing, synapsis, and recombination occur over an extended meiotic prophase I. In this study, we show that, in mice, maintenance of an extended meiotic prophase I requires the gene Meioc, a germ-cell specific factor conserved in most metazoans. Usi...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-27 | PXD005473 | Pride
Mouse Lc-ms/ms 
ProteomicsHuman genetics guides the discovery of novel CARD9 inhibitors with in vitro and in vivo anti-inflammatory activity
Human genetic association studies highlight key genes involved in disease pathology, yet targets identified by these analyses often fall outside the traditional definitions of druggability. A rare, truncated variant of the scaffold protein CARD9 is linked with protection from Crohn’s disease, promp...
ORGANISM(S): Homo sapiens (Human) 
2026-01-09 | PXD070429 | Pride
Lc-msms Pal Card9 
ProteomicsECM-enriched mouse lung - TMT-based quantitative mass spectrometry analysis was performed on ECM-enriched preparation from normal murine lung, bleomycin-induced fibrotic lung, primary tumors and lymph node metastasis isolated from the KrasG12D/+p53-/- mouse model of lung adenocarcinoma. Three independent samples were processed and analyzed for each condition. This study identified ECM signatures of normal and diseased lung tissue.
TMT-based quantitative mass spectrometry analysis was performed on ECM-enriched preparation from normal murine lung, bleomycin-induced fibrotic lung, primary tumors and lymph node metastasis isolated from the KrasG12D/+p53-/- mouse model of lung adenocarcinoma. Three independent samples were process...
ORGANISM(S): Mus musculus (Mouse) 
2017-06-21 | PXD003517 | Pride
Extraceullar matrix 
ProteomicsQuantitative proteomic analyses of budding yeast cells harboring an additional chromosome
Phenotypic variability is a hallmark of diseases involving chromosome gains and losses, such as Down Syndrome and cancer. Allelic variances have been thought to be the sole cause of this heterogeneity. Here, we systematically examine the consequences of gaining and losing single or multiple chromoso...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-04-10 | PXD006009 | Pride
Lc-ms/ms Yeast Aneuploid 
ProteomicsProteomic characterization of stem cell-derived extracellular matrices
We characterized and compared the proteomic composition of ECM produced in vitro by bone marrow-derived MSC, adipose-derived MSC and neonatal fibroblasts isolated from different donors, employing a multidimensional proteomic approach coupled with label-based quantitative proteomics. Each cell-derive...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080731 | MassIVE
TranscriptomicsExpression data for pharmacogenomics antiplatelet therapy
Antiplatelet therapy is the most important treatment to reduce the risk of developing recurrent thrombosis, and to prevent progression to a complete occlusion of coronary arterial disease (CAD) patients after percutaneous coronary intervention Aim of study was to investigate the relationship between...
ORGANISM(S): Homo sapiens 
2012-09-15 | E-GEOD-32226 | biostudies-arrayexpress
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