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ProteomicsIntergenerational control of ribosome levels upon dietary restriction
Living organisms adjust their proteome in response to nutritional conditions, but how these changes are transmitted across generations remains unclear. While unicellular organisms can inherit proteome states through symmetric division, multicellular organisms face limitations due to the soma-germlin...
ORGANISM(S): Caenorhabditis elegans 
2026-02-10 | PXD060999 | Pride
Intergenerational Ribosome Dietary restriction Proteome inheritance 
TranscriptomicsShort-term rapamycin treatment in mice have few effects on the transcriptome of white adipose tissue compared to dietary restriction
Analysis of the transcriptome in the epididymal fat of young mice (8 months of age) from treatment of dietary restriction, or rapamycin Total RNA extracted from epididymal fat of 8 month old C57BL6/J mice started on ad libitum (AL) , 40% dietary restriction (DR), or 14 ppm rapamycin (Rapa) from 2 mo...
ORGANISM(S): Mus musculus 
2014-08-18 | E-GEOD-52825 | biostudies-arrayexpress
TranscriptomicsCalorie/Dietary Restriction and Resveratrol in Female Drosophila Melanogaster Head/Thorax
Feeding resveratrol to Drosophila melanogaster extends lifespan. Studies of microarray show similarities between calorie/dietary restriction and resveratrol on both a gene expression and biological pathway level. 9 samples: 3 biological replicates each of normal diet, restricted diet and normal diet...
ORGANISM(S): Drosophila melanogaster 
2011-07-20 | E-GEOD-26724 | biostudies-arrayexpress
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
TranscriptomicsExpression Data From Dietary Restriction, p53 Knockdown and sir2 Overexpression Mutants
Expression data from four different lifespan-extending conditions: dietary restriction in two different genetic backgrounds (canton-s and a yw, w1118 combination), sir2 overexpression and p53 knockdown (+/-). Comparison of significantly over and under-expressed genes reveals a signature for dietary ...
ORGANISM(S): Drosophila melanogaster 
2011-01-20 | E-GEOD-26726 | biostudies-arrayexpress
ProteomicsDietary restriction transforms the mammalian protein sulfhydrome in a tissue-specific and cystathionine γ-lyase-dependent manner
Hydrogen sulfide (H2S) is a cytoprotective redox-active metabolite that signals through protein persulfidation (R-SSnH). Despite the known importance of persulfidation on relatively few identified proteins, tissue-specific sulfhydrome profiles and their associated functions are not well characterize...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-25 | PXD022954 | Pride
Persulfidation Longevity Dietary restriction (dr) Redox metabolism Cth) Cysteine Every other day (eod) fasting Biotin thiol assay (bta) Cse Cystathionine γ-lyase (cgl Sulfhydrome Hydrogen sulfide (h2s) Sulfhydration 
ProteomicsDrosophila melanogaster LC-MSMS
we performed proteome sequencing in Drosophila at day 7 (young) and day 42 (old) under dietary restriction (DR)and ad libitum (AL) conditions.
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-09-09 | PXD021022 | Pride
Lc-msms Drosophila Plasma 
TranscriptomicsTranslation profiling of Drosophila after dietary restriction
Analysis of the translational changes induced upon DR in male Drosophila. Experiment Overall Design: 1-2 day old flies were transferred onto 4% or 0.25% YE food for 6 days. ~100 male flies were then ground and RNA was separated by size on a sucrose gradient and fractionated using a Teledyne density...
ORGANISM(S): Drosophila melanogaster 
2009-10-09 | E-GEOD-16738 | biostudies-arrayexpress
ProteomicsDietary restriction transforms the mammalian protein sulfhydrome in a tissue-specific and cystathionine γ-lyase-dependent manner
Hydrogen sulfide (H2S) is a cytoprotective redox-active metabolite that signals through protein persulfidation (R-SSnH). Despite the known importance of persulfidation on relatively few identified proteins, tissue-specific sulfhydrome profiles and their associated functions are not well characterize...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-25 | PXD022956 | Pride
Persulfidation Longevity Dietary restriction (dr) Redox metabolism Cth) Cysteine Every other day (eod) fasting Biotin thiol assay (bta) Cse Cystathionine γ-lyase (cgl Sulfhydrome Hydrogen sulfide (h2s) Sulfhydration 
ProteomicsDietary restriction transforms the mammalian protein sulfhydrome in a tissue-specific and cystathionine γ-lyase-dependent manner
Hydrogen sulfide (H2S) is a cytoprotective redox-active metabolite that signals through protein persulfidation (R-SSnH). Despite the known importance of persulfidation on relatively few identified proteins, tissue-specific sulfhydrome profiles and their associated functions are not well characterize...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-25 | PXD022888 | Pride
Persulfidation Longevity Dietary restriction (dr) Redox metabolism Cth) Cysteine Every other day (eod) fasting Biotin thiol assay (bta) Cse Cystathionine γ-lyase (cgl Sulfhydrome Hydrogen sulfide (h2s) Sulfhydration 
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