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ProteomicsProteome Dynamics Underlying Drought Resistance Heterosis in Rice Flag Leaves
This study investigates the molecular mechanisms underlying drought resistance heterosis (DRH) in rice, specifically using the water-saving and drought-resistant rice hybrid Hanyou73 (HY73) and its parental lines Hanhui3 (HH3) and Huhan7B (HH7B). Given the significant impact of drought stress on glo...
ORGANISM(S): Oryza sativa (Rice) 
2026-06-28 | PXD064898 | Pride
Dia-ms Proteomic Flag leaf Heterosis Drought resistance Rice 
ProteomicsLysine acetylomic profiling of hybrid rice HY73 in response to drought
This study investigates the molecular mechanisms underlying drought-resistant heterosis (DRH) in the elite hybrid rice HY73. Utilizing a quantitative lysine acetylome profiling approach on flag leaves of HY73 under well-watered (WW) and drought-stressed (DS) conditions, we aimed to unravel the role ...
ORGANISM(S): Oryza sativa (Rice) 
2026-06-28 | PXD064916 | Pride
Hybrid rice Drought resistance Lysine acetylation Acetylome Heterosis 
ProteomicsInhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions
This project aimed to assess the role of pharmacological inhibition of the aryl hydrocarbon receptor (AhR) on skeletal muscle and cortical bone health in aged mice. As part of a broader systems biology approach, proteomic profiling was employed to investigate molecular mediators of neuromuscular jun...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-06 | PXD065529 | Pride
Lc-msms  aryl hydrocarbon receptor  proteomics 
ProteomicsArsenic Trioxide Acts as a Molecular Glue to Promote STUB1-Mediated NPM-ALK Degradation in ALK⁺ ALCL
The NPM-ALK fusion constitutively activates ALK tyrosine kinase, driving oncogenesis in anaplastic large cell lymphoma (ALCL). Although arsenic trioxide (ATO) exhibits therapeutic potential in NPM-ALK⁺ ALCL by inhibiting proliferation and inducing apoptosis, its molecular mechanism remains unclear. ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD074054 | Pride
Karpas299 Ato Targeted protein degradation Npm-alk+ alcl 
ProteomicsArsenic Trioxide Acts as a Molecular Glue to Promote STUB1-Mediated NPM-ALK Degradation in ALK⁺ ALCL
The NPM-ALK fusion constitutively activates ALK tyrosine kinase, driving oncogenesis in anaplastic large cell lymphoma (ALCL). Although arsenic trioxide (ATO) exhibits therapeutic potential in NPM-ALK⁺ ALCL by inhibiting proliferation and inducing apoptosis, its molecular mechanism remains unclear. ...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD073992 | Pride
Deslanoside Ato Targeted protein degradation Npm-alk+ alcl Stub1 Combination therapy 
ProteomicsPlasma proteomic profiling discovers molecular features associated with upper urinary tract urothelial carcinoma
Upper tract urothelial carcinoma (UTUC) is often diagnosed late and exhibits poor prognosis. Only limited data are available concerning potential noninvasive biomarkers for disease monitoring. Here, we investigated the proteomic profile of plasma in 362 UTUC patients and 239 healthy control samples....
ORGANISM(S): Homo Sapiens 
2023-07-12 | PXD043774 |
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