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ProteomicsDisintegrin-and-metalloproteinase-19 cleaves parathyroid hormone receptor and could cause brachydactyly type E
Brachydactyly type E (BDE), shortened metacarpals, metatarsals, cone-shaped epiphyses, and short stature, is an autosomal-dominant condition that commonly occurs as a sole phenotype. Parathyroid hormone-like protein (PTHrP) has been shown to be responsible in all forms to date, either directly or in...
ORGANISM(S): Homo sapiens (Human) 
2026-07-07 | PXD044793 | Pride
Human Parathyroid receptor Brachydactyly type e Shotgun proteomics Disintegrin-and-metalloproteinase-19 Lc-msms Gfp Parathyroid-related peptide 
UnknownGenetic and cellular studies highlight that A Disintegrin and Metalloproteinase 19 is a protective biomarker in human prostate cancer.
Not available
S-EPMC4766641 | biostudies-literature
ProteomicsAn integrative proteotranscriptomics approach reveals new ADAM9 substrates and downstream pathways
An integrative proteotranscriptomics approach to uncover the transcriptional and post-transcriptional targets of the disintegrin metalloproteinase ADAM9, a sheddase that has been implicated in solid tumors, autoimmunity, inflammatory diseases and COVID-19. This systematic approach revealed signaling...
ORGANISM(S): Homo sapiens (Human) 
2026-04-13 | PXD059109 | Pride
Multiomics Metalloproteinase Proteotranscriptomics Integration Adam9 Target identification 
GenomicsmiR-146b-5p downregulates IRAK1 and ADAM19 to suppress trophoblast proliferation, invasion and migration in miscarriage [miRNA profiles]
A large proportion of miscarriages are classified as unexplained miscarriages (UM) since no cause is identified. No reliable biomarkers or treatments are available for these pregnancy losses. While our transcriptomic sequencing has revealed substantial upregulation of miR-146b-5p in UM villous tissu...
ORGANISM(S): Homo sapiens 
2025-01-08 | GSE237733 | GEO
TranscriptomicsmiR-146b-5p downregulates IRAK1 and ADAM19 to suppress trophoblast proliferation, invasion and migration in miscarriage [circRNA, lincRNA, and mRNA profiles]
A large proportion of miscarriages are classified as unexplained miscarriages (UM) since no cause is identified. No reliable biomarkers or treatments are available for these pregnancy losses. While our transcriptomic sequencing has revealed substantial upregulation of miR-146b-5p in UM villous tissu...
ORGANISM(S): Homo sapiens 
2025-01-08 | GSE237732 | GEO
UnknownADAM19 cleaves the PTH receptor and associates with brachydactyly type E.
Not available
S-EPMC10853454 | biostudies-literature
UnknownMetalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike Protein.
Not available
S-EPMC9426510 | biostudies-literature
UnknownA disintegrin and metalloproteinase domain 9 facilitates SARS-CoV-2 entry into cells with low ACE2 expression.
Not available
S-EPMC10581035 | biostudies-literature
UnknownInsights Into Immunothrombosis: The Interplay Among Neutrophil Extracellular Trap, von Willebrand Factor, and ADAMTS13.
Not available
S-EPMC7738460 | biostudies-literature
UnknownAlpha-1-antitrypsin: A possible host protective factor against Covid-19.
Not available
S-EPMC7461031 | biostudies-literature
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