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Resource limitation is a major driver of ecological and evolutionary dynamics of organisms. Short-term responses to resource limitation include plastic changes in molecular phenotypes including protein expression. Yet little is known about the evolution of the molecular phenotype under longer-term r...
ORGANISM(S): Chlamydomonas reinhardtii 
2018-11-08 | PXD010847 | Pride
Although small RNAs efficiently control transposition activity of most transposons in the host genome, such immune system is not always applicable against new transposon's invasions. Here we explored a possibility to introduce potentially mobile copy of the Penelope retroelement previously implicate...
ORGANISM(S): Drosophila melanogaster 
We have performed small RNA sequencing in the nematodes Caenorhabditis elegans, C. briggsae, C. remanei and Pristionchus pacificus, which have diverged up to 400 million years ago, to establish the repertoire and evolutionary dynamics of miRNAs in these species. In addition to previously known miRN...
ORGANISM(S): Caenorhabditis elegans 
The dosage compensation complex (DCC) of Drosophila identifies its X chromosomal binding sites with exquisite selectivity. The principles that assure this vital targeting are known from the D. melanogaster model: DCC-intrinsic specificity of DNA binding, cooperativity with the CLAMP protein, and non...
ORGANISM(S): Drosophila virilis 
2021-06-23 | PXD023747 | Pride
Topological domains are key architectural building blocks of chromosomes in complex genomes. Their functional importance and evolutionary dynamics are however not well defined. Here we performed comparative Hi-C in liver cells from four mammalian species, and characterized the conservation and dive...
ORGANISM(S): Canis lupus familiaris 
Divergent clonal evolution and tumor microenvironment remodeling shape gastric cancer peritoneal metastasis
Cellular evolution of the hypothalamic preoptic area of behaviorally divergent deer mice
Chromatin accessibility is an important functional genomics phenotype that influences transcription factor binding and gene expression. Genome-scale technologies allow chromatin accessibility to be mapped with high-resolution, facilitating detailed analyses into the genetic architecture and evolutio...
ORGANISM(S): Saccharomyces cerevisiae x Saccharomyces paradoxus 
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