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ProteomicsMYC deregulation sensitizes cancer cells to N-myristoyltransferase inhibition - DoHH2 proteomics
Human N-myristoyltransferases (NMTs) catalyze N-terminal protein N-myristoylation and are promising targets in cancer, with an emerging mechanistic rationale for targeted therapy. Here, we screened 245 cancer cell lines against IMP-1320, a potent NMT inhibitor (NMTi), and conducted pathway-level ana...
ORGANISM(S): Homo sapiens (Human) 
2025-07-30 | PXD063851 | Pride
Proteomics Myc Nmt N-myristoylation Dohh2 
ProteomicsHLA class II peptidome analysis using data-dependent and data-independent acquisition
HLA class II peptides were purified from Maver-1 and DOHH2 cells and measured on the Q Exactive platform by data-dependent and data-independent acquisition.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-22 | MSV000081729 | MassIVE
TranscriptomicsSmall molecule inhibitor of BCL2 in combination with RCHOP is effective in CD20 negative lymphoma
Rituximab alone or in combination with chemotherapeutics is the first-line therapy for variety of lymphoproliferative disorders including low- and high grade non-Hodgkin’s lymphomas (NHL). Although the complete response rate is quite impressive, vast majority of patient presents recurrent disease. T...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-54201 | biostudies-arrayexpress
GenomicsTranscription differences in DLBCL cell lines U2932, DOHH2 on treatment with TK compound compared to DMSO
Transcription differences in DLBCL cell lines U2932, DOHH2 on treatment with TK compound compared to DMSO
PRJNA472014 | ENA
TranscriptomicsTranscriptome analysis of toosendanin (TSN)-treated DLBCL cells
The effects of TSN on total RNA expression were tested in DOHH2 cells using RNA-seq
ORGANISM(S): Homo sapiens 
2024-07-07 | GSE271299 | GEO
TranscriptomicsTranscriptome profiles of lymphoma cell lines after treatment with MZ1 compunds
4 lymphoma cell lines (DOHH2, OCILy10, TMD8 and Toledo) have been treated with MZ1. The transcriptome has been sequenced after 6hrs from the treatment
ORGANISM(S): Homo sapiens 
2023-06-01 | GSE152963 | GEO
TranscriptomicsEffect of combined AURK and BCL2 inhibition on gene expression in double-hit lymphoma xenografted mice
To investigate the mechanism behind drug synergism between MLN8237 and venetoclax we injected DoHH2 human tumor cells into SCID mice SQ, treated animals for 3 days, and harvested tumors for RNAseq.
ORGANISM(S): Homo sapiens 
2024-12-31 | GSE200410 | GEO
UnknownExpression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
Not available
S-EPMC9830372 | biostudies-literature
UnknownIntegrated multi-omics profiling reveals the ZZZ3/CD70 axis is a super-enhancer-driven regulator of diffuse large B-cell lymphoma cell-natural killer cell interactions.
Not available
S-EPMC11457841 | biostudies-literature
ProteomicsLC-MSMS of 3 DLBCL cell lines (class I immunopeptidome and whole proteome)
Accumulating evidence indicates that alternative translation events occur in all cell types, suggesting that the proteome is more complex than previously anticipated. We elected to broaden the repertoire of human cryptic proteins by designing an approach combining ribosome profiling, which gives a p...
ORGANISM(S): Homo sapiens (Human) 
2020-11-16 | PXD020620 | Pride
Lc-msms Dlbcl Hbl-1 Dohh2 Immunopeptidome Proteome And su-dhl-4 Mhc class i 
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