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UnknownHBL-1 patterns synaptic remodeling in C. elegans.
Not available
S-EPMC3278716 | biostudies-literature
UnknownSomatic gonad morphogenesis in C. elegans requires the heterochronic pathway acting through HBL-1.
Not available
S-EPMC12506653 | biostudies-literature
ProteomicsCharacterization of Primary Patient B-cells under Various Stimulation Conditions
The goal of this project was to compare the effects of differential stimulation of primary patient B-cells with CD40L, CpG, anti-IgM, and IL4 individually and in combination. Additionally, we observed a phenomenon where anti-IgM+CpG treatment resulted in a lymphoma-like phenotype and sought to compa...
ORGANISM(S): Homo sapiens (Human) 
2025-08-21 | PXD016961 | Pride
Human Igm B-cells Ms3 Tmt Immunology Cd40l Hbl-1 Sps-ms3 Cpg Il4 11-plex 
TranscriptomicsHighly Recurrent MYD88 Mutations That Promote Human Lymphoma Cell Survival
The ABC subtype of diffuse large B cell lymphoma (DLBCL) remains the least curable form of this lymphoma despite recent advances in therapy. We have combined structural and functional genomics to triangulate on new oncogenic mechanisms and devise new therapeutic strategies. RNA interference screen r...
ORGANISM(S): Homo sapiens 
2010-12-30 | E-GEOD-22900 | biostudies-arrayexpress
TranscriptomicsEssential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma
A key element for the development of suitable anti-cancer drugs is the identification of cancer-specific enzymatic activities that can be therapeutically targeted. Mucosa-associated lymphoid tissue transformation protein 1 (MALT1) is a proto-oncogene that contributes to tumorigenesis in diffuse larg...
ORGANISM(S): Homo sapiens 
2012-09-20 | E-GEOD-41034 | biostudies-arrayexpress
UnknownRegulation of nuclear-cytoplasmic partitioning by the lin-28-lin-46 pathway reinforces microRNA repression of HBL-1 to confer robust cell-fate progression in C. elegans.
Not available
S-EPMC6857590 | biostudies-literature
UnknownThe Caenorhabditis elegans pumilio homolog, puf-9, is required for the 3'UTR-mediated repression of the let-7 microRNA target gene, hbl-1.
Not available
S-EPMC2096746 | biostudies-literature
TranscriptomicsTime course gene expression profiling of five diffuse large B-cell lymphoma cell lines following JQ1 treatment
To understand the molecular curcuits perturbed by BET bromodoman inhibtion we obtained gene expression profiling of five DLBCL cell lines, SU-DHL6, OCI-Ly1, OCI-Ly4, Toledo and HBL-1, which were treated with either 500nM JQ1 or DMSO for 0,2,6,12,24 and 48hr. RNA samples from five DLBCL cell lines at...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-45630 | biostudies-arrayexpress
TranscriptomicsIkB-like protein NFKBIZ regulates NF-kB signaling and is critical for survival of ABC DLBCL (MALT inhibition)
Constitutive activation of the nuclear factor-kappa B (NF-kB) pathway is a hallmark of the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL). Recurrent mutations of NF-kB regulators that cause constitutive activity of this oncogenic pathway have been identified. However, i...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-46973 | biostudies-arrayexpress
TranscriptomicsIkB-like protein NFKBIZ regulates NF-kB signaling and is critical for survival of ABC DLBCL (MLN inhibition)
Constitutive activation of the nuclear factor-kappa B (NF-kB) pathway is a hallmark of the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL). Recurrent mutations of NF-kB regulators that cause constitutive activity of this oncogenic pathway have been identified. However, i...
ORGANISM(S): Homo sapiens 
2013-07-22 | E-GEOD-46972 | biostudies-arrayexpress
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