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ProteomicsProteomic analysis of Tks5 interactome to identify common marker of all types of invadosomes.
Invasion of the extracellular matrix is needed for physiological events such as wound healing but is also required at different stages of the metastatic process. The ability to progress and invade through the extracellular matrix is a characteristic shared by both normal and cancer cells through the...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-26 | PXD046512 | Pride
Invadosomes Nih cells Tks5 Quantitative proteome Translation 
ProteomicsProteomic analysis of Tks5 interactome to identify common marker of all types of invadosomes.
Invasion of the extracellular matrix is needed for physiological events such as wound healing but is also required at different stages of the metastatic process. The ability to progress and invade through the extracellular matrix is a characteristic shared by both normal and cancer cells through the...
ORGANISM(S): Homo sapiens (Human) 
2025-11-26 | PXD046515 | Pride
Invadosomes Tks5 Quantitative proteome Translation A431 cells 
ProteomicsA conserved AAA+ ATPase network regulates endoplasmic reticulum stress-induced transcription
In C. elegans cdc-48.2(-/-) mutant animals, ER stress-mediated expression of the UPR ckb-2::GFP reporter transgene is abolished. Here, we have used this phenotype in a genome-wide RNAi screen to identify genes involved in the CDC-48.2 mediated ER stress transcription. Combined with a comparative pro...
ORGANISM(S): Caenorhabditis elegans 
2015-09-30 | PXD000636 | Pride
Proteomic screen C. elegans Reptin Cdc-48 Rnai screen Vcp Endoplasmic reticulum stress P97 Ruvb-2 
ProteomicsProteomic analysis of the dpp3 knockout mutant, the reconstituted strain and the wild-type strain of Candida lusitaniae
Candida lusitaniae is an emerging human opportunistic yeast, which can switch from yeast to pseudohyphae, and one of the rare Candida species capable of sexual reproduction. Its haploid genome and the genetic tools available make it a model of interest to study gene function. This study describes th...
ORGANISM(S): Clavispora lusitaniae 
2023-05-02 | PXD020220 | Pride
Secondary mutation Quantitative proteome Candida Mating Cell separation Pseudo-hyphal growth 
ProteomicsQuantification of amyloid protein enrichment by mass spectrometry improves typing of amyloidosis
Amyloidosis typing is crucial to determine the best therapeutic strategy for patients. Since conventional histological techniques often fail, the identification of amyloid precursors by mass spectrometry became the new standard. However, without quantification, selecting the amyloid precursor from p...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD039814 | Pride
Proteomics Mass spectrometry Label-free quantification Amyloidosis typing 
ProteomicsProteomic analysis of primary human microvascular endothelial cells (HMVECs) stimulated for 24 h with either 50 ï�g/mL recombinant Fibrillin-1 C-terminal fragment or 25 ng/ml VEGF-A compared to unstimulated cells.
Mutations in the fibrillin-1 gene result in cardiovascular, ocular, and skeletal abnormalities in Marfan syndrome. Here we show that a fibrillin-1 mutation also alters the neovessel formation. In the mouse retina vascularization model, fibrillin-1 is detected at the basement membrane underlying the ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-31 | PXD029834 | Pride
Endothelial cell Quantitative proteome Angiogenesis 
ProteomicsComprehensive proteome profiling in Aedes albopictus to decipher Wolbachia-virus interference phenomenon
Cellular models have provided significant advances on molecular bases of bipartite interactions between either an arbovirus or a bacterial symbiont with a given arthropod vector. However, although an interference phenomenon was evidenced in tripartite interaction arbovirus-symbiont-mosquito vector v...
ORGANISM(S): Aedes <genus> 
2018-03-14 | PXD005091 | Pride
Quantitative proteomics Aedes albopictus Wolbachia Lc-ms Chikungunya virus 
ProteomicsProteomic analysis of genes regulated by miR-4510 in hepatocellular carcinoma
Patients with advanced hepatocellular carcinoma (HCC) are currently treated by Sorafenib and Regorafenib but efficacy of these multikinase inhibitors is disappointing. Thus, new drugs and therapies are needed to improve HCC management in clinic. We recently reported the remarkable capacity of miR-45...
ORGANISM(S): Homo sapiens (Human) 
2019-10-23 | PXD010085 | Pride
Cancer Liver Hepatocellular carcinoma Mir-4510 Label-free quantitative proteome analysis 
ProteomicsAdaptation to pH and pH signaling in the phytopathogenic fungus Botrytis cinerea
The grey mould fungus Botrytis cinerea is capable of developing on a wide variety of host plants and different organs that differ greatly in their pH values. The strategy developed by this necrotrophic fungus is partly based on the acidification of the plant tissues via the secretion of several orga...
ORGANISM(S): Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea) 
2021-09-13 | PXD004145 | Pride
Quantitative proteomics Ph-regulated genes Botrytis cinerea Lc-ms 
ProteomicsComparative proteomic analysis of the exoproteome of a wild type and cps1 mutant strains of the filamentous fungus Botrytis cinerea.
Botrytis cinerea is the causing agent of grey mould on hundreds of plants cultivated in fields, tunnels and greenhouses worldwide, including economically important crops. Considering the central role of the fungal cell wall in the interaction between fungi and plants, the role of a conserved putativ...
ORGANISM(S): Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea) 
2022-10-15 | PXD033590 | Pride
Botrytis cinerea Fungal cell wall Secretomics. 
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