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ProteomicsBiocompatible sulfonium-based covalent probes for endogenous tubulin fluorescence nanoscopy in live and fixed cells
Fluorescent probes enable the visualization of dynamic cellular processes with high precision, particularly when coupled with super-resolution imaging techniques that surpass the diffraction limit. Traditional methods include fluorescent protein fusion (e.g., GFP) or organic fluorophores linked to l...
ORGANISM(S): Sus Scrofa (ncbitaxon:9823) 
2025-11-18 | MSV000099944 | MassIVE
ProteomicsMolecular insights into THUMPD2-mediated m2G methylation of the U6 snRNA
THUMPD2 installs N2-methylguanosine (m2G) at position 72 of the U6 snRNA, and this modification, which lies at the catalytic core of the spliceosome, is required for efficient splicing of weak splice sites. However, when during the U6 lifecycle this modification is installed and what features of the...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD053510 | Pride
Dia Uhplc-esi-msms U6 snrna maturation Rna methylation Thumpd2 Trmt112 
ProteomicsMapping protein interactions in the active TOM-TIM23 supercomplex
Nuclear-encoded mitochondrial proteins destined for the matrix have to be transported across two membranes. The TOM and TIM23 complexes facilitate the transport of precursor proteins with N-terminal targeting signals into the matrix. During transport, precursors are recognized by the TIM23 complex i...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-12-13 | PXD028002 | Pride
Lc-msms Tim Mitochondria Translocation Structural modelling Tom23 Saccharomyces cerevisiae Crosslinking 
ProteomicsProvirus deletion from Haloferax volcanii affects motility, stress resistance and CRISPR RNA expression
Haloferax volcanii harbours four putative proviruses: Halfvol1, Halfvol2, Halfvol3 and Halfvol4. In this study we successfully deleted all four provirus genomes, demonstrating, that they are not essential. Transcriptome comparison between this strain (∆Halfvol1-4) and a wild type strain reveals an i...
ORGANISM(S): Haloferax volcanii (Halobacterium volcanii) 
2025-05-26 | PXD058393 | Pride
Provirus Haloferax volcanii Virus Motility Archaea Crispr rna 
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