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ProteomicsInteractome of the autoimmune risk gene product ANKRD55
The ankyrin repeat domain-55 (ANKRD55) gene contains intronic single nucleotide polymorphisms (SNPs) associated with risk to contract multiple sclerosis, rheumatoid arthritis or other autoimmune disorders. Risk alleles of these SNPs are associated with higher levels of ANKRD55 in CD4+ T cells. The b...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD013332 | Pride
Ankrd55 Ankyrin repeat Multiple sclerosis Rheumatoid arthritis Autoimmune 
ProteomicsIdentification of proximal SUMO-dependent interactors using SUMO-ID
Proximity-dependent labelling methods are based on promiscuous labeling enzymes that produce reactive molecules that covalently bind neighbor proteins. Labeled proteins can be then purified and identified using affinity-purification coupled to mass spectrometry methods23. Proximity-dependent biotin ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-20 | PXD027759 | Pride
Proteomics Lcms 
ProteomicsProteostasis disturbances and endoplasmic reticulum stress contribute to polycystic liver disease: new therapeutic targets.
Polycystic liver disease (PLD) is a group of genetic disorders characterized by bile duct dilatation and/or progressive development of multiple intrahepatic fluid-filled biliary cysts (>10), which are the main cause of morbidity. Current surgical and/or pharmacological therapies exert short-term and...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2020-05-25 | PXD017587 | Pride
Human and rat cholangiocytes Endoplasmic reticulum stress (er stress) 4-phenylbutyric acid (4-pba) Whole cell extracts Tims-tof pasef Polycystic liver disease (pld) Peaksq Perseus. Proteostasis 
ProteomicsNeddylation inhibition halts acetaminophen induced liver injury boosting anabolic cardiolipin pathway
Drug Induced-liver injury (DILI) is a significant cause of acute liver failure (ALF) and liver transplantation in the Western world. APAP overdose is a main contributor of DILI, leading to hepatocyte cell death through necrosis. Herein, we identified that neddylation, an essential post-translational...
ORGANISM(S): Mus Musculus 
PXD053221 |
ProteomicsProtein Profile of Bovine Oviductal Extracellular Vesicles
The study of early maternal-embryonic cross-talk remains one of the most challenging topics in reproductive biology. Understanding the physiological mechanisms involved in the interactions between the maternal reproductive tract and the developing embryo is essential for enhancing bovine reproductiv...
ORGANISM(S): Bos Taurus 
PXD053670 |
ProteomicsHuman serum extracellular vesicle proteomic profile depends on the enrichment method employed
The proteomic profiling of serum samples supposes a challenge due to the large abundance of few blood proteins in comparison with other circulating proteins coming from different tissues and cells. Although the sensitivity of protein detection has increased enormously in the last years, to enrich le...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD029015 | Pride
Ultracentrifugation Extracellular vesicles Serum Precipitation kits Size exclusion Proteomic 
ProteomicsProteomic evaluation of human osteoblast responses to titanium implants over time
Titanium is widely used in bone prostheses due to its excellent biocompatibility and osseointegration capacity. To understand the effect of sandblasted acid-etched (SAE) Ti implants on the biological responses of human osteoblast (HOb), their proteomic profiles were analysed using nLC-MS/MS. The cel...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035986 | Pride
Titanium Human osteoblasts Label free 
ProteomicsProteomics reveals differential diagnosis biomarkers between sepsis and hemophagocytic syndrome
Hemophagocytic Lymphohistiocytosis (HLH) shares many clinical features with sepsis. To improve HLH diagnosis and its differential diagnosis with sepsis, serum proteomic analyses of healthy donors, HLH and septic patients were performed. In this study, 24 individuals were enrolled in a label free MS/...
ORGANISM(S): Homo sapiens (Human) 
2026-01-05 | PXD063444 | Pride
Hemophagocytic syndrome Sepsis Label free 
ProteomicsPotential tear biomarkers for the early diagnosis of Parkinson's disease- A pilot study
Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. The purpose of this study was to analyze the profile of the tear proteome of patients with idiopathic PD (iPD), carriers of the E46K-SNCA mutation and healthy subjects (CT) and to identify biomark...
ORGANISM(S): Homo sapiens (Human) 
2022-02-14 | PXD028811 | Pride
Biomarkers  parkinson’s disease  tear film  lysosome 
ProteomicsTear protein profile in eyes with keratoconus after one year of intrastromal corneal ring and corneal crosslinking: a pilot study
Keratoconus (KC) is a corneal ectasia characterized by structural changes, resulting in progressive thinning and biomechanical weakening that can lead to worsening visual acuity due to irregular astigmatism. Corneal collagen Crosslinking (CXL) and Intracorneal Ring Segment (ICRS) are widely used tr...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD035655 | Pride
Keratoconus Intracorneal ring segment Crosslinking Tear film 
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