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ProteomicsProteome changes of RPE-1 cells in response to lysosomal damage with the TAK1 inhibitor
The lysosomal damage response plays a critical role in the maintenance of cellular homeostasis. While the repair and autophagic elimination mechanisms of damaged lysosomes have been elucidated, the early signal transduction and subsequent gene expression in response to lysosomal damage remain elusiv...
ORGANISM(S): Homo sapiens (Human) 
2025-08-30 | PXD058075 | Pride
Dia Human cell Lc-ms Lysosomal damage 
ProteomicsProteome changes of RPE-1 cells in response to lysosomal damage
The lysosomal damage response plays a critical role in the maintenance of cellular homeostasis. While the repair and autophagic elimination mechanisms of damaged lysosomes have been elucidated, the early signal transduction and subsequent gene expression in response to lysosomal damage remain elusiv...
ORGANISM(S): Homo sapiens (Human) 
2025-08-30 | PXD058072 | Pride
Dia Human cell Lc-ms Lysosomal damage 
ProteomicsPhosphoproteome changes of RPE-1 cells in response to lysosomal damage with the TAK1 inhibitor
The lysosomal damage response plays a critical role in the maintenance of cellular homeostasis. While the repair and autophagic elimination mechanisms of damaged lysosomes have been elucidated, the early signal transduction and subsequent gene expression in response to lysosomal damage remain elusiv...
ORGANISM(S): Homo sapiens (Human) 
2025-08-30 | PXD058080 | Pride
Phosphoproteome Human cell Lc-ms Lysosomal damage Dda 
ProteomicsHuman Nrf1 interactome upon proteasome inhibition
Nuclear factor erythroid-derived 2 related factor 1 (NFE2L1/Nrf1), an endoplasmic reticulum (ER)-associated transcription factor, is responsible for the coordinated expression of proteasome subunit genes upon proteasomal dysfunction. N-glycosylated proteins undergo protein sequence editing by peptid...
ORGANISM(S): Homo sapiens (Human) 
2025-12-14 | PXD065838 | Pride
Nrf1 Proteasome 
ProteomicsThe dissociation of RQT complex on ribosome
Ribosome-associated quality control (RQC) represents a rescue pathway in eukaryotic cells triggered upon translational stalling. Collided ribosomes are recognized for subsequent dissociation followed by targeting of the faulty nascent peptides for degradation. However, endogenous RQC inducing sequen...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-02-24 | PXD017196 | Pride
Yeast In vitro reaction Ribosome 
ProteomicsDNMT1 IP-MS alalysis to identify ubiquitin-dependent interacting partners
Stable inheritance of DNA methylation is critical for maintaining the differentiated phenotypes in multicellular organisms. However, the molecular basis ensuring high fidelity of maintenance DNA methylation is largely unknown. Here, we demonstrate that two distinct modes of DNMT1 recruitment, one is...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2020-02-25 | PXD015282 | Pride
Dnmt1 ubiquitin 
ProteomicsFLAG-Ub IP/MS of USP8-depleted cells
The analysis to identify ubiquitinated proteins increased on endosomes in USP8-depleted cells.
ORGANISM(S): Homo sapiens (Human) 
2023-12-17 | PXD042488 | Pride
Ubiquitin Endosome Usp8 
ProteomicsTMT 6-plex proteome analyisis of USP8-depleted cells
The analysis to investigate the change in proteome of USP8-depleted cells
ORGANISM(S): Homo sapiens (Human) 
2023-12-17 | PXD042490 | Pride
Ubiquitin Endosome Usp8 
ProteomicsUbiquitin remnant profiling for identification of the ubiquitylation sites in mysterin
Ubiquitin remnants obtained from the cells expressing variants of ubiquitin ligase mysterin were analyzed by mass spectrometry to identify the ubiquitylation sites in mysterin. HN indicates the RING finger mutant (H4014N). RZ indicates the RZ finger mutant (H4509A). A1A2 indicates the ATPase mutant ...
ORGANISM(S): Homo sapiens (Human) 
2026-10-02 | PXD055333 | Pride
Lc-msms Ubiquitinome Human cells 
ProteomicsTMTpro 16-plex analysis of siRAD23B and siControl in replicatively and ETP-treated senescent cells
Replicatively-senescent and ETP-treated senescent WI-38 cells were transfected with siRNAs (Stealth Select RNAi RAD23B siRNA #1 and siGENOME non-targeting control siRNA #2) using Lipofectamine RNAiMAX in four biological replicates. At 72 h after transfection, the cells were washed twice with cold-PB...
ORGANISM(S): Homo Sapiens (human) 
2023-07-22 | PXD028626 | JPOST Repository
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