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MetabolomicsPolystyrene nanoparticles promote endometrial cancer development through the ACSS2-mediated reprogramming of arachidonic acid metabolism

Microplastics and nanoplastics are commonly found in our everyday environments. So far, microplastics and nanoplastics have been detected in various tissues and bodily fluids, including hair, sputum, digestive tissue, lungs, blood, and placental tissue. Although some studies indicate that micropl...

2026-02-05 | MTBLS13850 | MetaboLights
TranscriptomicsAn improved method for the isolation of endometrial epithelial and stromal cells from the total hysterectomy specimen
We aimed to improve the efficiency of isolating endometrial epithelial and stromal cells (EMECs and EMSCs) from hysterectomy specimens. We revealed by immunohistochemical staining that the large tissue fragments remaining after collagenase treatment, which are usually discarded after the first filtr...
ORGANISM(S): Homo sapiens 
2016-06-14 | E-GEOD-73090 | biostudies-arrayexpress
TranscriptomicsDifferential expression of Wnt signalling molecules between pre- and post-menopausal endometrial epithelial cells suggests that a population of putative epithelial stem/progenitor cells reside in the basalis layer
The human endometrium is a highly regenerative tissue that undergoes cyclical proliferation, differentiation and shedding each month. The upper functionalis layer of the endometrium is shed in response to circulating levels of estrogen and progesterone, while the lower basalis layer remains. Clonoge...
ORGANISM(S): Homo sapiens 
2012-04-10 | E-GEOD-35221 | biostudies-arrayexpress
TranscriptomicsCOUP-TFII regulates human endometrial stromal genes involved in inflammation
Although the function of COUP-TFII in uterine decidualization has been described in mice, its role in the human uterus remains unknown.To interrogate the role of COUP-TFII in human endometrial function, we utilized a siRNA-mediated loss of function approach in primary human endometrial stromal cells...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-47052 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of endometrial epithelial cells (EECs) to understand actions of tamoxifen in the uterus and its molecular effectors in endometrial carcinogenesis
The molecular explanation for tamoxifen serving as a breast cancer treatment but displaying partial estrogenic in the uterus is not known. Previously, we reported that differential promoter context and cofactor recruitment contribute to the tissue specificity of tamoxifen. Here, we investigated the ...
ORGANISM(S): Homo sapiens 
2007-09-08 | E-GEOD-3013 | biostudies-arrayexpress
ProteomicsMyosin Heavy Chain 10 dysregulation in infertile endometrial epithelial cells impairs adhesive capacity
Endometrial receptivity is defined as the functional, morphological, and molecular changes of the endometrium occurring during a limited time period in the menstrual cycle called the ‘window of implantation’. The endometrial luminal epithelial cells are critical in producing this receptivity as thei...
ORGANISM(S): Homo sapiens (Human) 
2026-05-05 | PXD062326 | Pride
Endometrial receptivity Epithelium Endometrial Cell adhesion Actin cytoskeleton Infertility Myh10 Myosin 2 Embryo implantation failure 
TranscriptomicsRNA-seq of Pluripotent Stem Cell-Derived Endometrial Stromal Fibroblasts in Monolayer Differentiation and in Co-culture with Endometrial Epithelial Organoids
H9 Pluripotent Stem Cells (PSC) were differentiated to Endometrial Stromal Fibroblasts (PSC-ESF) in monolayer over the course of 12 days. Gene expression was measured at day 0, day 4, day 8, and day 12 of differentiation. At day 12, PSC-ESF were dissociated from monolayer culture for co-culture with...
ORGANISM(S): Homo sapiens 
2021-05-05 | E-MTAB-10375 | biostudies-arrayexpress
ProteomicsSECRETORY PROTEOMIC RESPONSES OF ENDOMETRIAL EPITHELIAL CELLS TO TROPHOBLAST DERIVED EXTRACELLULAR VESICLES
Synchronized cross talk between embryo and endometrium during pre-implantation period is critical for establishment of pregnancy. Extracellular vesicels(EVs) of both embryo and endometrial origin are known to be integral in regulating embryo maternal communication during this time. However, exact mo...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD040311 | Pride
Embryo Extracellular vesicles Lc-ms Endometrium Epithelial cells Trophoblast cells Secretome Proteomics 
GenomicsSSEA-1+ and SSEA-1- endometrial epithelial cells
SSEA-1+ and SSEA-1- endometrial epithelial cells
PRJNA1177846 | ENA
TranscriptomicsSingle-cell RNA-seq of Endometrial organoids treated with NOTCH or WNT inhibitors in a time course of Estrogen and Progesterone stimulation
We performed single-cell RNA-sequencing of 3D endometrial organoid cultures in order to dissect the signaling pathways that determine cell fate of epithelial lineages. Every time course was obtained in a background that either included or did not include ovarian hormones stimulation, which emulates ...
ORGANISM(S): Homo sapiens 
2021-07-21 | E-MTAB-10283 | biostudies-arrayexpress
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