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ProteomicsFAM134B oligomerization drives ER membrane scission for ER-phagy
ER degradation by selective autophagy (ER-phagy) is crucial for ER homeostasis. However, it remains unclear how ER scission is regulated for subsequent autophagosomal sequestration and lysosomal degradation. Here, we show that oligomer formation of FAM134B (also referred to as reticulophagy regulato...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD016661 | Pride
Er-phagy  fam134b oligomerization  membrane fragmentation  er stress  camk2b 
ProteomicsThe intrinsically disordered regions of organellophagy receptors control organelle fragmentation, ER-phagy and mitophagy flux
Organelle fragmentation is crucial for the onset of autophagic programs that control lysosomal clearance of portions of organelles to be removed from cells. It is driven by membrane-bound organello-phagy receptors that display cytoplasmic intrinsically disordered modules (IDRs) containing short LC3-...
ORGANISM(S): Homo sapiens (Human) 
2025-07-16 | PXD060519 | Pride
Fragmentation Intrinsically disordered regions Er-phagy Mitochondria Endoplasmic reticulum 
ProteomicsFam20C interactome in the secretory pathway under ER stress
Accumulated unfolded proteins in the endoplasmic reticulum (ER) will trigger the unfolded protein response (UPR) to increase protein-folding capacity. The ER proteostasis and UPR signaling should be precisely and timely regulated. In the project, by unbiased proteomics analysis, we identify that the...
ORGANISM(S): Homo sapiens (Human) 
2020-03-02 | PXD016619 | Pride
Fam20c Pdi Er stress Phosphorylation 
UnknownALS/FTD-associated mutation in cyclin F inhibits ER-Golgi trafficking, inducing ER stress, ERAD and Golgi fragmentation.
Not available
S-EPMC10665471 | biostudies-literature
ProteomicsThe function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways.
Selective autophagy of the endoplasmic reticulum (ER), known as ER-phagy, is an important regulator of ER remodeling and is critical to maintaining cellular homeostasis during environmental changes. We recently showed that members of the FAM134 family play a role during stress-induced ER-phagy. How...
ORGANISM(S): Homo sapiens (Human) 
2023-11-16 | PXD043003 | Pride
Ck2 Er homeostasis Lysosomal degradation Er remodeling Er fragmentation Chek1 Atr Selective autophagy Atm Ubiquitination. Stress response Fam134b Fam134c Endoplasmic reticulum Mtor 
UnknownC9orf72-Associated Dipeptide Repeat Expansions Perturb ER-Golgi Vesicular Trafficking, Inducing Golgi Fragmentation and ER Stress, in ALS/FTD.
Not available
S-EPMC11584443 | biostudies-literature
TranscriptomicsTranscription profiling of immortalized B cells from unrelated individuals and twins undergoing ER stress
The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) results in the condition called “ER stress” which induces the unfolded protein response (UPR) which is a complex cellular process that includes changes in expression of many genes. Failure to restore homeostasis...
ORGANISM(S): Homo sapiens 
2010-04-08 | E-GEOD-19519 | biostudies-arrayexpress
TranscriptomicsGSTP1 expression predicts poor pathological complete response to neoadjuvant chemotherapy in ER-negative breast cancer
The purpose of the present study was to investigate the association of glutathione S-transferase P1 (GSTP1) expression with resistance to neoadjuvant paclitaxel followed by 5-fluorouracil/epirubicin/cyclophosphamide (P-FEC) in human breast cancers. The relationship of GSTP1 expression and GSTP1 prom...
ORGANISM(S): Homo sapiens 
2012-03-20 | E-GEOD-32646 | biostudies-arrayexpress
UnknownThe intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux.
Not available
S-EPMC12431859 | biostudies-literature
TranscriptomicsInduction of ER stress in HCT116 colon cancer cells
To investigate the role of p53 and DICER in the induction of ER stress, wildtype, p53 knockout or DICER mutant HCT116 colon cancer cells were treated with the ER stress inducers tunicamycin or brefeldin A for 24 hours. Microarray analysis was used to determine changes in gene expression associated w...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-63252 | biostudies-arrayexpress
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