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MetabolomicsEx-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study
Osteoarthritis (OA) is an age-related degenerative musculoskeletal disease characterised by loss of articular cartilage, synovitis, abnormal bone proliferation and subchondral bone sclerosis. Underlying OA pathogenesis is yet to be fully elucidated with no OA specific biomarkers in clinical use. Ex-...
2020-09-30 | MTBLS1495 | MetaboLights
ProteomicsProteomic analysis of dexamethasone effects on cartilage breakdown
An in vitro explant culture model of cartilage breakdown (post-traumatic osteoarthritis), where explant media mimics the synovial fluid. The OA model was induced by cytokine treatment with or without injury and potential therapeutic treatment was investigated by adding dexamethasone. Proteins releas...
ORGANISM(S): Bos taurus (Bovine) 
2020-09-14 | PXD020756 | Pride
Proteomics Osteoarthritis Cartilage Explant culture Bovine 
GenomicsIgnition of supporting cell activation for hair cell regeneration in the avian auditory epithelium: an explant culture model
Ignition of supporting cell activation for hair cell regeneration in the avian auditory epithelium: an explant culture model
PRJNA646062 | ENA
UnknownA bovine nucleus pulposus explant culture model.
Not available
S-EPMC9542046 | biostudies-literature
ProteomicsEx-Vivo Equine Cartilage Explant Osteoarthritis Model - A Metabolomics and Proteomics Study
Osteoarthritis (OA) is an age-related degenerative musculoskeletal disease characterised by loss of articular cartilage, synovitis, abnormal bone proliferation and subchondral bone sclerosis. The underlying pathogenesis of OA is yet to be fully elucidated with no OA specific biomarkers in clinical u...
ORGANISM(S): Equus caballus (Horse) 
2020-08-03 | PXD017153 | Pride
Metabolomics Mass spectrometry Nuclear magnetic resonance Cartilage Proteomics Osteoarthritis 
UnknownThe Inflammatory Landscape of a Whole-Tissue Explant Model of Hidradenitis Suppurativa.
Not available
S-EPMC11811487 | biostudies-literature
UnknownMurine Hind Limb Explant Model for Studying the Mechanobiology of Achilles Tendon Impingement.
Not available
S-EPMC11952120 | biostudies-literature
UnknownEstablishment of a striped catfish skin explant model for studying the skin response in Aeromonas hydrophila infections.
Not available
S-EPMC8463585 | biostudies-literature
ProteomicsTissue Catabolism and Donor-Specific Dexamethasone Response in a Human Osteochondral Model of Post-Traumatic Osteoarthritis
We present an ex vivo human osteochondral model of PTOA to investigate disease effects on catabolism and cellular homeostasis in a multi-tissue system and discover biomarkers for disease progression and drug efficacy.
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD032213 | Pride
Proteomics Ptoa model Osteochondral Explant culture Dexamethasone 
TranscriptomicsGenome-wide DNA methylation identifies trophoblast invasion-related genes: Claudin-4 and Fucosyltransferase IV control mobility via altering matrix metalloproteinase activity
Previously we have shown that extravillous cytotrophoblast (EVT) outgrowth and migration on a collagen gel explant model were restricted by exposure to decidual natural killer cells (dNK). This study investigates the molecular causes behind this phenomenon. Genome wide DNA methylation of exposed and...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-60885 | biostudies-arrayexpress
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