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ProteomicsGlutamate utilization fuels rapid production of mitochondrial ROS in dendritic cells and drives systemic inflammation following Francisella infection
Dendritic cells (DCs) hijacked by intracellular bacteria contribute to pathogen dissemination and immunopathology. How bacteria achieve DC subversion remains largely unknown. Here, we describe the mechanism used by intracellular pathogen Francisella tularensis exploiting host mitochondria. Shortly a...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-21 | PXD055084 | Pride
Acetylome Francisella tularensis Dendritic cells Tca cycle Reactive oxygen species Glutamate Mitochondria 
ProteomicsAcetylome analysis of Bordetella pertussis reveals possible targets of novel BP0960 gene-encoded lysine deacetylase
Acetylation on ε-amino groups of lysine residues (N-ε-lysine acetylation) represents an important mechanism of post-translational regulation of protein function. However, its role and extent in the whooping cough agent Bordetella pertussis remain unknown. In this study, we analyzed the acetylomes of...
ORGANISM(S): Bacteria Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) 
2020-07-19 | PXD016384 | Pride
Acetylome Bordetella pertussis Deacetylase activity 
ProteomicsTargets of kinase/phosphatase signalling pair StkP/PhpP in S. pneumoniae and their involvement in response to cell wall stress
Streptococcus pneumoniae is an opportunistic human pathogen which encodes a single eukaryotic-type Ser/Thr protein kinase StkP and its functional counterpart protein phosphatase PhpP. These signalling enzymes play a crucial role in the coordination of cell division and growth in pneumococcus. In thi...
ORGANISM(S): Streptococcus pneumoniae Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) Streptococcus pneumoniae (strain ATCC BAA-255 / R6) 
2022-05-12 | PXD024033 | Pride
Phosphatase phpp Phosphoproteome Cell wall stress Ser/thr protein kinase stkp Signalling Ampicillin treatment Streptococcus pneumoniae 
ProteomicsPhosphoproteomics of cAMP signaling of adenylate cyclase toxin in mouse dendritic cells
The whooping cough agent, Bordetella pertussis, subverts dendritic cell (DCs) functions through powerful immunomodulatory activities of its toxins. Here we focused on the signaling action of the adenylate cyclase toxin (CyaA) that targets myeloid cells expressing the αMβ2 integrin CD11b/CD18 (known ...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-29 | PXD004733 | Pride
Adenylate cyclase toxin Bone marrow-derived dendritic cells Bordetella pertussis Phosphoproteome 
ProteomicsLung macrophages utilize unique cathepsin K-dependent phagosomal machinery to degrade intracellular collagen
Resident tissue macrophages (RTMs) are organ-specialized phagocytes responsible for the maintenance and protection of residing tissue. It is well established that tissue diversity is reflected by the heterogeneity of RTMs origin and phenotype. However, much less is known about tissue-specific phagoc...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-18 | PXD033010 | Pride
Phagocytosis Proteomics Cathepsins Resident tissue macrophages Phagosome maturation 
ProteomicsPhosphoproteome analysis of bone marrow-derived dendritic cells infected by Francisella tularensis – proteome dataset
Francisella tularensis is a highly infective Gram-negative bacterium, also known as the causative agent of tularemia. The disease is characterized by the delayed onset of the adaptive immune response which provides time for the bacterial replication. As an intracellular pathogen, Francisella prolife...
ORGANISM(S): Mus musculus (Mouse) Francisella tularensis subsp. holarctica FSC200 
2017-10-26 | PXD006759 | Pride
Francisella tularensis Bone marrow-derived dendritic cells Mapk signaling Phosphoproteome 
ProteomicsPhosphoproteome analysis of bone marrow-derived dendritic cells infected by Francisella tularensis
Francisella tularensis is a highly infective Gram-negative bacterium, also known as the causative agent of tularemia. The disease is characterized by the delayed onset of the adaptive immune response which provides time for the bacterial replication. As an intracellular pathogen, Francisella prolife...
ORGANISM(S): Mus musculus (Mouse) Francisella tularensis subsp. holarctica FSC200 
2017-10-26 | PXD005747 | Pride
Francisella tularensis Bone marrow-derived dendritic cells Mapk signaling Phosphoproteome 
ProteomicsMemantine administration enhances glutamatergic and GABAergic pathways in human hippocampus of Alzeimer´s disease patients
Alzheimer´s disease (AD) represents a serious health, social and economic problem. One of the traditional treatment is administration of memantine, the NMDA receptor antagonist. In this study we investigated how memantine medication impacts protein expression in hippocampus of AD patients using TMT-...
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD052958 | Pride
Memantine  ffpe  alzheimer´s disease  proteomics  hippocampus  glutamate receptors  metabolism 
ProteomicsIsobaric labeling-based quantitative proteomics of cells purified from the intestine of Crohn’s disease patients reveals immune cell-epithelial cell crosstalk of potential importance in disease pathogenesis
Crohn's disease (CD) is a chronic condition characterized by recurrent flares of inflammation of the gastrointestinal tract. Despite decades of research, the etiology of CD is poorly understood and is characterized by dysregulated immune activation that progressively destroys the gastrointestinal ti...
ORGANISM(S): Homo sapiens (Human) 
2023-01-02 | PXD036591 | Pride
Immune cells Tmt labeling Epithelial cells Cell sorting Crohn’s disease 
ProteomicsAltered ceramide metabolism is a feature in the extracellular vesicle mediated spread of alpha-synuclein in sporadic and GBA-linked Lewy body disease
Mutations in glucocerebrosidase (GBA) are the most prevalent genetic risk factor for Lewy body disorders (LBD) – collectively Parkinson’s disease, Parkinson’s disease dementia and dementia with Lewy bodies. Despite this genetic association, it remains unclear how GBA mutation contributes to the susc...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD026980 | Pride
Exosomes Alpha-synuclein Ceramide Inflammation Lewy body disease Extracellular vesicles Glucocerebrosidase 
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