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TranscriptomicsPatterns of micro RNA expression characterize stages of human B-cell differentiation
Mature B-cell differentiation provides an important mechanism for the acquisition of adaptive immunity. Malignancies derived from mature B-cells constitute the majority of leukemias and lymphomas. These malignancies often maintain the characteristics of the normal B-cells that they are derived from,...
ORGANISM(S): Homo sapiens 
2009-03-16 | E-GEOD-15250 | biostudies-arrayexpress
GenomicsExome-sequencing of human B cell lymphoma cell lines
26 cell lines derived from human Diffuse Large B Cell lymphomas (DLBCL) or Burkit Lymphomas (BL) were subjected to whole exome sequencing. Exome capture was carried out using the SeqCap EZ Exome Library 2.0 kit (Roche/Nimblegen) and 100 bp single-read sequencing was performed on a HiSeq2500 (Illumin...
EGAS00001001463 | EGA
ProteomicsA variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes
Transcriptional regulation by chromatin is a highly dynamic process directed through the recruitment and coordinated action of epigenetic modifiers and readers of these modifications. Using an unbiased proteomic approach to find interactors of H3K36me3, a modification enriched on active chromatin, w...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-07-19 | PXD010445 | Pride
Nurd Pwwp2a/b Hdac 
UnknownFischer carbene catalysis of alkynol cycloisomerization: application to the synthesis of the altromycin B disaccharide.
Not available
S-EPMC4604442 | biostudies-literature
ProteomicsB cell Lymphomas present Immunoglobulin Neoantigens
Immunoglobulin gene rearrangement and somatic hypermutation have the potential to create neoantigens in non-Hodgkin B cell lymphoma. However, the presentation of these putative immunoglobulin neoantigens by B cell lymphomas has not been proven. We used MHC immunoprecipitation followed by liquid chr...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD010808 | Pride
Lymphoma Neoantigens Mhc Orbitrap 
GenomicsEssential role of the transcription factors E2A and E2-2 in germinal center B cell and plasma cell development
E2A is an essential regulator of early B-cell development. Here we demonstrated that E2A together with E2-2 controlled germinal-center B-cell and plasma cell development. As shown by identification of regulated E2A,E2-2 targets in activated B-cells, these E-proteins directly activated genes with imp...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-77744 | biostudies-arrayexpress
GenomicsMolecular role of the PAX5-ETV6 oncoprotein in promoting B cell acute lymphoblastic leukemia
PAX5 is a tumor suppressor in B-ALL, while the role of PAX5 fusion proteins in B-ALL development is largely unknown. Here we studied the function of PAX5-ETV6 and PAX5- FOXP1 in mice expressing these proteins from the Pax5 locus. Both proteins arrested Blymphopoiesis at the pro-B-to-pre-B cell trans...
ORGANISM(S): Mus musculus 
2016-07-30 | E-GEOD-84987 | biostudies-arrayexpress
ProteomicsTargeting G1–S Checkpoint–Compromised Cancers with Cyclin A/B RxL Inhibitors
Cancer cell proliferation requires precise control of E2F1 activity; excess activity promotes apoptosis. Here, we developed cell-permeable and bioavailable macrocycles that selectively kill small cell lung cancer (SCLC) cells with inherent high E2F1 activity by blocking RxL-mediated interactions of ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-30 | PXD055112 | Pride
Macrocycle Cyclin a E2f Cyclin b Cy/rxl motif Cdk2 Sac Synthetic lethality 
TranscriptomicsTranscription profiling of human NIH-3T3 fibroblasts stably expressing the coxsackie-adenovirus receptor (CARI?1)) cells were transduced with adenovirus containing empty vector (AdEmpty) followed by addition of vehicle (DMSO) or transduced with adenovirus encoding either full length HA-tagged PPARg2 or A/B-domain deleted HA-PPARgCDE and treated with rosiglitazoneNIH-3T3 fibroblasts stably expressing the coxsackie-adenovirus receptor (CARI?1)) cells were transduced with adenovirus containing empty vector (AdEmpty) followed by addition of vehicle (DMSO) or transduced with adenovirus encoding either full length HA-tagged PPARg2 or A/B-domain deleted HA-PPARgCDE and treated with rosiglitazone reveals the PPARg2 A/B-domain plays a gene specific role in transactivation and co-factor recruitment
We have previously shown that adenoviral expression of peroxisome proliferator-activated receptors (PPARs) leads to rapid establishment of transcriptionally active complexes and activation of target gene expression within 5-8 h following transduction. Here we have used the adenoviral delivery system...
ORGANISM(S): Mus musculus 
2009-04-04 | E-GEOD-15433 | biostudies-arrayexpress
ProteomicsCharacterization of novel human cystatin B salivary interactome in Alzheimer’s disease and healthy subjects.
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease in the elderly, characterized by the accumulation in the brain of misfolded proteins, inflammation, and oxidative damage leading to neuronal cell death. The necessity of searching for new non-invasive biomarkers in tissues or b...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD030679 | Pride
Coip Proteomics Alzheimer Cystatinb Lc-msms Interactome 
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