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MetabolomicsIntegrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE‐mediated pediatric cow's milk allergy

BACKGROUND: IgE-mediated cow's milk allergy (IgE-CMA) is one of the first allergies to arise in early childhood and may result from exposure to various milk allergens, of which β-lactoglobulin (BLG) and casein are the most important. Understanding the underlying mechanisms behin...

2024-02-15 | MTBLS6768 | MetaboLights
GenomicsActivation and repression by oncogenic Myc shapes tumour-specific gene expression profiles
In mammalian cells, the Myc oncoprotein binds to thousands of promoters. During mitogenic stimulation of primary lymphocytes, Myc promotes an increase in expression of virtually all genes. In contrast, Myc-driven tumour cells differ from normal cells in expression of specific sets of up- and downreg...
ORGANISM(S): Homo sapiens 
2014-07-10 | E-GEOD-44672 | biostudies-arrayexpress
ProteomicsBacteria in biogas digestates for reduced climate forcing
Mitigation of N2O-emissions from soils is needed to reduce climate forcing by food production. Inoculating soils with N2O-reducing bacteria would be effective, but costly and impractical as a standalone operation. Here we demonstrate that digestates obtained after biogas production may provide a low...
ORGANISM(S): unclassified Azonexus 
2022-02-16 | PXD023233 | Pride
Denitrification N2o-reduction Isolate Azonexus sp. Lc-msms. Anaerobic digestion Dechloromonas sp 
ProteomicsImproved peptide backbone fragmentation is the primary advantage of MS-cleavable crosslinkers
Proteome-wide crosslinking mass spectrometry studies have coincided with the advent of MS-cleavable crosslinkers that can reveal the individual masses of the two crosslinked peptides. However, recently such studies have also been published with non-cleavable crosslinkers suggesting that MS-cleavabil...
ORGANISM(S): Mus musculus (Mouse) Escherichia coli Drosophila melanogaster (Fruit fly) 
2022-06-24 | PXD032821 | Pride
Lc-msms Dsbu Ms-cleavable crosslinker Dsso Crosslinking Clms 
ProteomicsMnx1 Induces Leukemia Transformation Through Altering Histone Methylation in a Model of Pediatric t(7;12) Acute Myeloid Leukemia
Acute myeloid leukemia (AML) in children with cytogenetic aberrations like translocation t(7;12)(q36;p13) is associated with inferior outcome. The translocation can lead to a fusion transcript MNX1::ETV6 but also to activation of MNX1 transcription. We generated an AML mouse model by transplantatio...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-30 | PXD034416 | Pride
Aml Mnx1::etv6 Homeodomain T(7 12) Pediatric aml Mnx1 Methyl-transferases 
TranscriptomicsGenomic variation and adaptation in fragmented landscapes
We have compared allelic and gene expression variation using individual-based RNA-seq data from four regional populations of the Glanville fritillary butterfly (Melitaea cinxia) in northern Europe. Two of the populations represent fragmented habitat and two continuous habitat. Based on sequence info...
ORGANISM(S): Melitaea cinxia 
2014-07-04 | E-GEOD-47692 | biostudies-arrayexpress
GenomicsEpo-Induced Erythroid Maturation Is Dependent on Plcγ1 Signaling
Erythropoiesis is a tightly regulated process. Development of red blood cells occurs through differentiation of hematopoietic stem cells into more committed progenitors and finally into erythrocytes. Binding of erythropoietin to its receptor (EpoR) is strictly required for erythropoiesis as it promo...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-60087 | biostudies-arrayexpress
UnknownDrug screening identifies tazarotene and bexarotene as therapeutic agents in Multiple Sulfatase Deficiency
Not available
S-SCDT-10_15252-EMMM_202114837 | biostudies-other
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